张梅芳,李德微,童子康,等.孔石莼多糖抗病毒活性及作用机制的初探[J].中国海洋药物,2025,(6):-. |
孔石莼多糖抗病毒活性及作用机制的初探 |
Preliminary exploration of the antiviral activity and the potential mechanism of ulvan derived from Ulva pertusa |
投稿时间:2024-04-01 修订日期:2024-05-23 |
DOI: |
中文关键词: 孔石莼多糖 抗病毒活性 天然免疫 I型干扰素 |
English Keywords:ulvan antiviral innate immune IFN-I |
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中文摘要: |
目的 评价孔石莼多糖的抗病毒活性,探索其抗病毒活性的分子机制,为石莼多糖的后续开发提供理论支撑。方法 运用病毒感染、流式细胞术等分子生物学和病毒学手段,在细胞模型中评估孔石莼多糖对病毒感染抑制活性,及其对相关信号通路的影响。结果 孔石莼多糖显著抑制VSV病毒(水疱型口炎病毒)感染,作用机制研究表明孔石莼多糖可激活天然免疫,诱导I型干扰素(IFN-Ⅰ)表达,抵抗病毒感染。 |
English Summary: |
Abstract: Objective To estimate the antiviral activities of ulvan derived from Ulva pertusa, and initiate a preliminary exploration into its mechanism, for the potential utilization of ulvans in the future. Methods Employing methodologies rooted in molecular biology and virology, such as viral infection and FACS, the effect of ulvan on virus infection and the innate immune responses in cells were evaluated. Results Ulvan significantly restricted VSV (Vesicular stomatitis virus) infection. Preliminary exploration on its mechanism indicated that ulvan activated the innate immune, and induced type I interferons (IFN-Ⅰ) expression to restrict viral infection |
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