| 杨庆星,于海勇,曹中阳,等.Welwitindolinone C的全合成研究[J].中国海洋药物,2025,(3):-. |
| Welwitindolinone C的全合成研究 |
| Studies on the Total Synthesis of Welwitindolinone C |
| 投稿时间：2024-03-05 修订日期：2024-03-23 |
| DOI： |
| 中文关键词: Welwitindolinone C全合成 螺环内酯化合物 螺环内酰胺化合物 吲哚啉化合物 |
| English Keywords:total synthesis of Welwitindolinone C Spirolactone spirolactam indoline |
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| 中文摘要: |
| 目的 对海洋天然产物 Welwitindolinone C 的全合成研究中意外得到了三个结构新颖的化合物。方法 以已知化合物cis-Pulegol和3-取代吲哚为起始原料,依次经过Meerwein-Eschenmoser-Claisen重排,环氧化和甲基化得到关键中间体,之后进行Meinwald重排反应和环氧开环反应的尝试。结论 关键中间体在不同反应条件下可以分别高效地得到具有螺环内酯,螺环内酰胺以及吲哚啉结构的多环骨架化合物,化合物的结构最终由单晶X射线衍射确证。 |
| English Summary: |
| Abstract: Objective In the study of the total synthesis of marine natural product Welwitindolinone C, three compounds with novel structures were unexpectedly obtained. Methods The key intermediates were obtained by Meerwein-Eschenmoser-Claisen rearrangement, epoxidation and methylation using the known compound cis-Pullegol and 3-substituted indole as the starting materials, and then the Meinwald rearrangement reaction and epoxy ring opening reaction were carried out. Results The key intermediates can efficiently obtain polycyclic skeleton compounds with spirolactone, spirolactam and indoline structures under different reaction conditions. The structures of the compounds were finally confirmed via X-ray crystallography. |
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