| 康永锋,门晓玲,江习习,等.中国南海软珊瑚Lemnalia sp.中的化学成分及其生物活性研究（英文）[J].中国海洋药物,2025,(3):-. |
| 中国南海软珊瑚Lemnalia sp.中的化学成分及其生物活性研究（英文） |
| Chemical components and biological activities of Soft Coral Lemnalia sp. from the South China Sea |
| 投稿时间：2023-12-15 修订日期：2024-04-02 |
| DOI： |
| 中文关键词: 软珊瑚 Lemnalia sp. 西松烷二萜 生物活性 |
| English Keywords:soft coral Lemnalia sp. cembranoid diterpene bioactivity. |
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| 中文摘要: |
| 目的 研究中国南海软珊瑚Lemnalia sp.的化学成分并进行生物活性评价。方法 综合运用各种层析方法分离纯化化合物，利用现代波谱分析方法并结合文献对化合物结构进行鉴定，并测定所有化合物的抗菌活性、免疫抑制活性和酶抑制活性。结果 从珊瑚中分离得到1个新西松烷二萜类化合物Lemnaliaterpenoid A（1）和3个已知化合物sinulaparvalide A（2）、dihydrosinuflexolide（3）和capillolide（4），化合物1对金黄色葡萄球菌和大肠杆菌显示抗菌活性，最低抑菌浓度（MIC）分别为16、16 μg/mL，化合物1~3对Jurkat细胞有抑制作用，浓度为5 μg/mL时，抑制率分别为64.0%、67.8%和49.4%，化合物1~4对醛糖还原酶都没有抑制活性。结论 从南海软珊瑚Lemnalia sp.中分离到4个西松烷二萜类化合物，包含1个新的，其中新化合物1有一定的抑菌作用和细胞毒作用，这些化合物的发现表明软珊瑚Lemnalia sp.可以作为发现结构新颖且具有生物活性化合物的重要来源。 |
| English Summary: |
| Objective To investigate the chemical constituents and biological activities of soft coral Lemnalia sp. from the South China Sea. Methods The chemical constituents were isolated and purified by various chromatographic techniques. The structures of all compounds were elucidated by using the modern spectrum analysis methods and comparison with the literature data. The antibacterial, immunosuppressive, and enzyme inhibitory activities of these compounds were evaluated. Results A new cembranoid diterpene, lemnaliaterpenoid A (1), and three known compounds, sinulaparvalide A (2), dihydrosinuflexolide (3), and capillolide (4) were isolated from the soft coral Lemnalia sp.. Compound 1 showed antibacterial activity against Staphylococcus aureus and Escherichia coli with MIC values of 16, 16 μg/mL, respectively. Compounds 1?3 displayed immunosuppressive activity against ConA-induced T cell (Jurkat cell) proliferation with inhibitory rates of 64.0%, 67.8%, and 49.4%, respectively, at a concentration of 5 μg/mL. Compounds 1?4 did not demonstrate enzyme inhibitory activity against the aldose reductase. Conclusion Four diterpenoid compounds were isolated from the soft coral Lemnalia sp. derived from the South China Sea, including one new cembranoid diterpene. Among them, the new compound 1 exhibits antibacterial and cytotoxic activities. The soft coral Lemnalia sp. from the South China Sea were prolific resources that produced structurally novel and biologically active secondary metabolites. |
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