王美霞,肖艳芳,雷玉,等.中国南海海绵Haliclona baeri的化学成分研究?[J].中国海洋药物,2022,(5):-.
中国南海海绵Haliclona baeri的化学成分研究?
Studies on Chemical Constituents of the Sponge Haliclona baeri from the South China Sea
投稿时间:2021-06-23  修订日期:2021-08-26
DOI:
中文关键词:  海绵  Haliclona baeri  化学成分  吲哚生物碱
English Keywords:sponge  Haliclona baeri  chemical constituents  indole alkaloids
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作者单位邮编
王美霞 揭阳职业技术学院 522000
肖艳芳 暨南大学 化学与材料学院 
雷玉 暨南大学 化学与材料学院 
徐石海 暨南大学 化学与材料学院 
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中文摘要:
      目的 对采自中国南海海域海绵Haliclona baeri 95 %乙醇提取物的乙酸乙酯部位的化学成分进行研究。方法 运用薄层色谱、正相Silica gel柱色谱、SephadexLH-20柱色谱以及HPLC等色谱分离手段;通过NMR、MS等波谱学方法,并结合文献报道,鉴定化合物的结构。结果 从海绵H. baeri中分离并鉴定了5个吲哚生物碱,分别为:(1H-indol-3-yl) oxoacetamide (1)、1H-indole-3-acetamide (2)、1H-indole-3-ethylethanoate (3)、1H-indole-3-carboxylic acid ethyl ester (4)和1H-indole-3-carboxylic acid (5)。结论 化合物1-4为首次从该属海绵中分离得到。对化合物1进行生物活性测试,该化合物没有表现出明显的细胞毒、抗核因子κB、抗菌、抗病毒和抗污损活性。
English Summary:
      Objective To research the chemical components of the ethyl acetate fraction of the 95 % ethanol extract of the sponge Haliclona baeri collected from the South China Sea. Methods These compounds were separated and purified by modern chromatographic separation technology such as TLC, silica gel, Sephadex LH-20, HPLC and so on, and their structures were identified by the means of NMR, MS and other spectroscopy methods, furthermore, by combaring with literature reports. Results Five indole alkaloids were separated and purified from the sponge H. baeri, those compounds were identified as (1H-indol-3-yl) oxoacetamide (1)、1H-indole-3-acetamide (2)、1H-indole-3-ethylethanoate (3)、1H-indole-3-carboxylic acid ethyl ester (4) and 1H-indole-3-carboxylic acid (5). Conclustion Compounds 1-4 were all isolated from this genus for the first time. Compound 1 showed no obvious cytotoxic, anti-nuclear factor κB, antibacterial, antiviral and antifouling activities.
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