| 俞蕴嘉,张洋,王伟.靶向病毒核糖核蛋白的抗流感病毒药物研究进展[J].中国海洋药物,2019,38(3):82-86. |
| 靶向病毒核糖核蛋白的抗流感病毒药物研究进展 |
| Progress in research on anti-influenza virus drugs targeting viral ribonucleoprotein |
| 投稿时间：2019-02-25 修订日期：2019-03-25 |
| DOI： |
| 中文关键词: 流感病毒 核糖核蛋白 新靶点 抗病毒药物 天然产物 |
| English Keywords:Influenza virus ribonucleoprotein new target antiviral drugs natural product |
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| 中文摘要: |
| 流行性感冒病毒所导致的人畜共患病长久以来威胁着人类的健康，但目前可用于临床的抗流感病毒药物十分有限，且逐渐出现了病毒耐药性的问题。因此，研究者们近来致力于探究新型抗流感药物靶点的发现，并期望针对新靶点设计疗效好且不易发生耐药的抗流感病毒药物。流感病毒核糖核蛋白具有不同毒株间保守性高，在病毒复制周期中作用广泛的特点，是设计开发新型抗流感药物的潜在靶点。本文对目前临床使用的抗流感药物靶点、核糖核蛋白的结构与功能及其相关药物的研究进展进行了综述，以期为新型抗流感药物的研发提供参考。 |
| English Summary: |
| The zoonotic disease flu caused by the influenza virus has long threatened human health, but there are very limited anti-influenza drugs available for clinical use, and the problem of virus resistance has gradually emerged. Therefore, Therefore, researchers have recently been working on the discovery of new anti-influenza drug targets, and expect to design novel anti-IAV drugs with good efficacy and low risk of inducing drug resistance. Influenza virus ribonucleoprotein has high conservativeness among different strains and play a wide role in the replication cycle of influenza viruses. Thus, virus ribonucleoprotein can be a potential target for the design and development of novel anti-influenza drugs. This article is aimed to review the the current research progress on the target of anti-IAV drugs in clinical, the structure and function of ribonucleoprotein and related drugs, so as to provide reference for the research and development of novel anti-influenza drugs. |
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