| 亓玉,穆新蕊,王雅茹,等.海洋中药抗炎活性成分的作用机制与转化应用前景分析[J].中国海洋药物,2027,(3):-. |
| 海洋中药抗炎活性成分的作用机制与转化应用前景分析 |
| Anti-inflammatory Components from Marine Chinese Medicines: Mechanisms and Translational Applications |
| 投稿时间：2026-01-29 修订日期：2026-04-10 |
| DOI： |
| 中文关键词: 海洋中药 抗炎作用 活性成分 作用机制 转化策略 |
| English Keywords:marine traditional Chinese medicines anti-inflammatory effects active ingredients mechanisms of action transformation strategies |
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| 中文摘要: |
| 炎症相关疾病高发且现有临床药物存在局限性，开发新型抗炎药物具有重要价值。海洋中药源于特殊海洋生境，富含结构新颖的抗炎活性成分。本文围绕“基原生境-物质成分-作用机制”主线，梳理其基原类型、“性-味-归经”与地理分布特征，分析了硫酸化糖链、特殊甾醇、黄酮、酚类、“萜-醌”杂合物及活性肽等代表性抗炎成分与靶点规律。结果显示，相关品种以藻类与海洋动物为主，药性多偏寒或微寒，药味以咸、甘为主，归经集中于肝、肾、脾、肺等。机制上，亲水性糖链主要调控TLR4/CD14及NF-κB、MAPK通路，脂溶性小分子干预COX-2、5-LOX或激活PPARα，活性肽兼具炎症信号抑制与ROS/Nrf2/HO-1轴激活功能，体现了多成分协同调控优势。面向转化应用，提出以“来源可控、成分可量化、靶点证据可闭环”为导向的策略，为海洋中药抗炎创新药物与功能产品研发提供参考。 |
| English Summary: |
| Inflammatory-related diseases are widespread, and current clinical drugs have limitations. Thus, developing new anti-inflammatory drugs is crucial. Marine traditional Chinese medicines (MTCMs), derived from unique marine habitats, encompasses a variety of novel anti-inflammatory active components. The article utilizes the framework of "origin habitat - chemical components - action mechanism" to elucidate MTCMs that possess anti-inflammatory properties. It discusses their characteristics, flavors, meridian tropisms, and geographical distribution. Additionally, the article examines the correlation patterns between key anti-inflammatory components, including sulfated polysaccharides, specific sterols, flavonoids, phenolic compounds, terpene-quinone hybrids, and active peptides, along with their respective targets. The results show that algae and marine animals are the primary sources. Most have cold or slightly cold properties, with salty and sweet flavors, and their meridian tropisms focus on the liver, kidney, spleen, and lung. At the molecular level, hydrophilic sugar chains target TLR4/CD14 receptors and signal hubs like NF-κB and MAPK, while lipophilic small molecules affect synthesis enzymes such as COX-2 and 5-LOX or activate PPARα. Active peptides exhibit a dual action by inhibiting inflammatory signals and activating the ROS/Nrf2/HO-1 cell protection axis. For translational applications, a strategy focused on "controllable sources, quantifiable components, and closed-loop target evidence" is proposed to guide the research and development of innovative anti-inflammatory drugs and functional products derived from MTCMs. |
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