于淑晴,辛少帅,董宇晴,等.海洋真菌心血管保护活性天然产物的研究进展[J].中国海洋药物,2026,(1):-. |
海洋真菌心血管保护活性天然产物的研究进展 |
Research progress on natural products from marine fungi with cardiovascular protective activities |
投稿时间:2024-05-07 修订日期:2024-12-03 |
DOI: |
中文关键词: 海洋真菌 天然产物 活性成分 心血管保护 |
English Keywords:marine fungi natural products active ingredients cardiovascular protection |
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中文摘要: |
近年来,心血管疾病已经成为严重威胁人类健康的常发病,全世界每年死于心血管疾病的人数高达1500万人,居各种死因首位。由于现有药物存在药效低、副作用强等弊端,寻找高活性、无毒或低毒性的心血管药物成为新药研究的一项重要课题。海洋真菌拥有独特的生存环境,能够代谢产生结构新颖、活性丰富的天然产物。研究表明,大量来源于海洋真菌的天然产物具有心血管保护活性。本文总结了前人的研究成果,从降血脂、抗血栓、促血管生成、降血压、心脏保护、抗氧化这六方面,对海洋真菌来源的心血管保护天然产物进行综述,为心血管药物的进一步研究开发提供参考。 |
English Summary: |
In recent years, cardiovascular diseases have become a serious threat to human health and a common cause of death. Every year, about 15 million people die from cardiovascular diseases worldwide, ranking first among all causes of death. Due to the drawbacks of existing drugs, such as low efficacy and strong side effects, finding highly active, non-toxic or low-toxic cardiovascular drugs has become an important topic in new drug research. Marine fungi have unique living environments and can metabolize novel and diverse natural products. Studies have shown that many natural products derived from marine fungi have cardiovascular protective activities. |
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