薛莹,周月,张雅慧,等.柳珊瑚来源真菌Penicillium chrysoygenum中的1个新的α吡喃酮发现(英文)[J].中国海洋药物,2024,43(2):29-34.
柳珊瑚来源真菌Penicillium chrysoygenum中的1个新的α吡喃酮发现(英文)
A New α-Pyrone from the Gorgonian-Derived Fungus Penicillium chrysogenum
投稿时间:2023-02-26  修订日期:2023-03-09
DOI:10.13400/j.cnki.cjmd.2024.02.001
中文关键词:  柳珊瑚来源  Penicillium chrysogenum  聚酮  ECD  抗真菌活性
English Keywords:gorgonian-derived fungus  Penicillium chrysogenum  polyketide  ECD, antifungal activity
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作者单位E-mail
薛莹 中国海洋大学 海洋药物教育部重点实验室 18340851586@163.com 
周月 中国海洋大学 海洋药物教育部重点实验室 ouc_zhouyue@163.com 
张雅慧 中国海洋大学 海洋药物教育部重点实验室 15689932652@163.com 
杨毅 太原理工大学 yangyi01@tyut.edu.cn 
王长云* 中国海洋大学 海洋药物教育部重点实验室 changyun@ouc.edu.cn 
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中文摘要:
      目的 柳珊瑚来源真菌Penicillium chrysogenum (TA10-16)次级代谢产物及其生物活性研究。方法 通过广泛的波谱数据,包括1D/2D NMR,HRESIMS和ECD谱从而确定化合物的结构。结果 共分离获得7个聚酮化合物,包括1个新的α-Pyrone(1)和6个已知化合物(2–7)。化合物1和6对白色念珠菌表现出中等的抗真菌活性,MIC值为12.5 μmol/L,而化合物7对白色念珠菌的MIC值则为25.0 μmol/L。结论 化合物1的结构通过1D/2D NMR、HRESIMS和ECD等综合光谱数据进行了鉴定。同时,通过活性测试,化合物1和6具有潜在的抗真菌活性。
English Summary:
      Objective The secondary metabolites from the gorgonian-derived fungus Penicillium chrysogenum (TA10–16) and their biological activities. Methods The structure of the compounds were identified by comprehensive spectroscopic data, including 1D/2D NMR, HRESIMS and ECD. Results Seven polyketide compounds were isolated from a marine fungus Penicillium sp., including a new α-Pyrone (1) and six known compounds (2–7). Compounds 1 and 6 showed moderate antifungal activity against Candida albicans with the same MIC values of 12.5 μmol/L, while compound 7 showed weak activity against C. albicans with the MIC value of 25.0 μmol/L. Conclusion The structure of compound 1 was elucidated by comprehensive spectroscopic data including 1D/2D NMR, HRESIMS and ECD. At the same time, compounds 1 and 6 have potential antifungal activity through activity test.
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