| 张岗,陈忠茂,阮加陈,等.红树植物老鼠簕内生真菌橘青霉P4-5-1中的1个新异喹啉酮生物碱[J].中国海洋药物,2023,42(3):31-35. |
| 红树植物老鼠簕内生真菌橘青霉P4-5-1中的1个新异喹啉酮生物碱 |
| A new isoquinolone alkaloid from Penicillium citrinum P4-5-1, an endophytic fungus isolated from mangrove plant Acanthus ilicifolius |
| 投稿时间：2023-01-16 修订日期：2023-02-28 |
| DOI：10.13400/j.cnki.cjmd.2023.03.002 |
| 中文关键词: 老鼠簕 内生真菌 橘青霉 化学成分 结构鉴定 |
| English Keywords:Acanthus ilicifolius endophytic fungus Penicillium citrinum constituents structural identification |
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| 中文摘要: |
| 目的 研究老鼠簕内生真菌橘青霉(Penicillium citrinum)P4-5-1的化学成分。方法 利用正反相硅胶柱色谱、Sephadex LH-20凝胶柱色谱以及半制备高效液相色谱等技术对P4-5-1次生代谢产物进行分离,利用高分辨质谱、一维及二维核磁共振等波谱鉴定技术确定化合物结构。结果 从P4-5-1大米发酵物中分离得到了6个化合物,分别为4-methoxy-2-methylisoquinolin-1(2H)-one (1)、fischexanthone (2)、penicitrinone A (3)、ent-aspergoterpenin C (4)、sydowiol E (5)和citrinin (6)。结论 化合物1为新异喹啉酮生物碱,命名为citrinadin D；化合物2、4和5首次从该种真菌中获得。 |
| English Summary: |
| Objective To study the chemical constituents of Penicillium citrinum P4-5-1, an endophytic fungus isolated from Acanthus ilicifolius L. Methods Silica gel column chromatography, ODS reversed phase column chromatography, sephadex LH-20 chromatography and semi-preparative high performance liquid chromatography were used to isolate the secondary metabolites of P4-5-1, and the high resolution mass spectrometry (HR-MS) and nuclear magnetic resonance spectroscopy (1D- and 2D-NMR) were employed to identify structures of isolates. Results A total of 6 compounds were obtained from the EtOAc extract of the fungal rice culture and identified as 4-methoxy-2-methylisoquinolin-1(2H)-one (1), fischexanthone (2), penicitrinone A (3), ent-aspergoterpenin C (4), sydowiol E (5) and citrinin (6), respectively. Conclusion Compound 1 was a new isoquinolone alkaloid and named citrinadin D. Compounds 2, 4 and 5 were obtained from this fungus for the first time. |
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