| 符安冉,肖丽,唐旭利,等.西沙软珊瑚Lemnalia sp.倍半萜类次级代谢产物研究[J].中国海洋药物,2024,43(1):54-59. |
| 西沙软珊瑚Lemnalia sp.倍半萜类次级代谢产物研究 |
| Studies on secondary metabolites of sesquiterpenoids from a Xisha soft coral Lemnalia sp. |
| 投稿时间：2022-11-25 修订日期：2023-03-02 |
| DOI：10.13400/j.cnki.cjmd.2024.01.004 |
| 中文关键词: Lemnalia sp. 倍半萜 次级代谢产物 |
| English Keywords:Lemnalia sp. sesquiterpenoids secondary metabolites |
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| 中文摘要: |
| 目的 对采自西沙群岛的软珊瑚样品Lemnalia sp.进行倍半萜类次级代谢产物的研究。方法 利用薄层色谱、硅胶柱层析、中压制备液相色谱和高效液相色谱等现代分离手段对软珊瑚浸膏进行分离、纯化,得到单个化合物；综合运用核磁共振、质谱等现代波谱学方法,通过与文献报道的数据进行对比,对所分离化合物的结构进行鉴定。结果 从西沙软珊瑚Lemnalia sp.中分离鉴定得到10个倍半萜类化合物,分别为Lemnardosinanes D (1)、flavalin E (2)、paralemnolin R (3)、Pathylactone A (4)、(+)-13-hydroxy-aristlone (5)、Laevinone A (6)、(+)-curcudiol (7)、oplodiol (8)、6-Eudesmene-1β, 4β-diol (9)、Paralemnolide A (10)。结论 从软珊瑚Lemnalia sp.中分离得到10个已知的倍半萜类化合物,其化学结构类型分别属于nardosinane型、nornardosinane型、aristolane型、neolemnane型、bisabolane型、eudesmane型和bisnorsesquiterpene型,其中化合物4、5、7~10是首次在该属软珊瑚中发现的倍半萜。 |
| English Summary: |
| Objective To investigate the chemical structures of sesquiterpenoids isolated from a soft coral Lemnalia sp. collected from the Xisha Islands. Methods The compounds in the soft coral crude extract were isolated and purified by TLC, silica gel column chromatography, MPLC and HPLC. Various modern spectroscopy technologies (NMR spectroscopy, MS, etc.) and comparison with the reported data were carried out to identify the structures of the compounds. Results Ten sesquiterpenoids were isolated from Lemnalia sp. and were identified as Lemnardosinanes D (1)、flavalin E (2)、paralemnolin R (3)、Pathylactone A (4)、(+)-13-hydroxy-aristlone (5)、Laevinone A (6)、(+)-curcudiol (7)、oplodiol (8)、6-Eudesmene-1β, 4β-diol (9)、Paralemnolide A (10). Conclusion Ten known sesquiterpenoids with nardosinane, nornardosinane, aristolane, neolemnane, bisabolane, eudesmane and bisnorsesquiterpene-type skeletons were isolated from a soft coral Lemnalia sp. Compounds 4、5、7~10 were obtained from soft corals of the genus Lemnalia for the first time. |
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