| 汪巾岳,何云海,马志超,等.岩藻聚糖硫酸酯降血糖作用机制的研究进展[J].中国海洋药物,2023,42(5):71-80. |
| 岩藻聚糖硫酸酯降血糖作用机制的研究进展 |
| Research progress on hypoglycemic mechanism of fucoidan |
| 投稿时间：2022-05-12 修订日期：2022-10-14 |
| DOI：10.13400/j.cnki.cjmd.2023.05.003 |
| 中文关键词: 岩藻聚糖硫酸酯 结构 分子量 降血糖活性 作用机理 |
| English Keywords:Fucoidan structure molecular weight hypoglycemic mechanism |
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| 中文摘要: |
| 糖尿病是以高血糖和胰岛素抵抗为特征的内分泌和代谢系统疾病，已成为世界范围内一种普遍疾病。岩藻多糖基于其特定的化学结构，如单糖组成和糖苷键，具有良好的降糖作用和理想的糖尿病治疗潜力。岩藻聚糖硫酸酯具有多种生物活性，但其结构复杂、高分子量和高粘性的特性限制了其应用，而低分子量岩藻多糖粘度低、溶解度好，且研究表明低分子量岩藻多糖具有更好的降血糖作用，因此其低分子量产物的研究具有重大意义。本文讨论了岩藻多糖的结构特征，包括主干结构、糖苷键位置、单糖类型、硫酸盐含量，着重介绍了多糖分子量和降血糖活性的关联，继而引申出低分子量降血糖作用及其作用机理，以期为明晰岩藻多糖的构效关系及进一步的应用提供理论基础。 |
| English Summary: |
| Diabetes mellitus is a disease of the endocrine and metabolic systems characterized by hyperglycemia and insulin resistance, and has become a prevalent disease worldwide. Based on its specific chemical structure, such as monosaccharide composition and glycosidic bond, fucoidan has good hypoglycemic effect and ideal potential in the treatment of diabetes. Fucoidan has various biological activities, however, its use is limited due to a number of reasons including complex structure, high molecular weight and high viscosity, while low molecular weight fucoidan has lower viscosity and good solubility, and better hypoglycemic effect, that make the research of low molecular weight fucoidan of great significance. This paper presents the structural characteristics of fucoidan, including backbone structure, glycosidic bond, monosaccharide composition, sulfate content, and highlights the relationship between polysaccharide molecular weight and hypoglycemic activity, and then extends the hypoglycemic effect and the mechanism of low molecular weight, in order to provide a theoretical basis for clarifying the structure-activity relationship of fucoidan and further applications. |
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