陈欣桐,王悦,宋玉娟,等.顶空气相色谱法测定藻酸双酯钠丙二醇酯基取代程度[J].中国海洋药物,2022,41(3):43-49.
顶空气相色谱法测定藻酸双酯钠丙二醇酯基取代程度
Determination of the propylene glycol ester group substitution degree of Propylene glycol alginate sodium sulfate by headspace gas chromatography
投稿时间：2021-05-31  修订日期：2021-07-06
DOI：
中文关键词:  气相色谱法  顶空进样  藻酸双酯钠  丙二醇酯基取代程度  1,2-丙二醇
English Keywords:gas chromatography  headspace sampling  propylene glycol alginate sodium sulfate(PSS)  propylene glycol ester group substitution degree  1,2-propylene glycol
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作者单位E-mail
陈欣桐 中国食品药品检定研究院生化药品室 841920846@qq.com 
王悦 化学药品质量研究与评价重点实验室 wangyue07@nifdc.org.cn 
宋玉娟 中国食品药品检定研究院生化药品室 syj200206@126.com 
刘博 中国食品药品检定研究院生化药品室 liubo1057@nifdc.org.cn 
范慧红* 中国食品药品检定研究院生化药品室 shenghuayaoshi@126.com 
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中文摘要:
      目的 建立藻酸双酯钠丙二醇酯基取代程度的气相测定方法。方法 利用强碱碱解藻酸双酯钠丙二醇酯基为1,2-丙二醇，按顶空气相色谱法进样分析。气相色谱柱为DB-WAX毛细管色谱柱（30 m×0.32 mm，0.5 μm），载气为氮气，顶空平衡温度120℃，程序升温，氢火焰离子化检测器（FID）。结果 1,2-丙二醇质量浓度在0.1~3.0 mg·mL-1范围内线性关系良好（r=0.9995），精密度RSD小于3%。 结论 该方法灵敏度高、准确性好，有助于完善藻酸双酯钠质量标准研究，减少不良反应的发生。
English Summary:
      Abstract: Objective To establish a method for the detection of 1,2-propanediol in alkaline hydrolysis solution to determine propylene glycol ester group substitution degree of Propylene glycol alginate sodium sulfate (PSS). Methods Hydrolyzed propylene glycol ester group of PSS to 1,2-propanediol with strong base, determined by headspace gas chromatography. The column was DB-WAX (30 m×0.32 mm, 0.5 μm); the carrier gas was nitrogen; headspace equilibrium temperature was 120 ℃, temperature programming method, hydrogen flame ionization detector (FID). Results The linearity of 1,2-propanediol was good within the range of 0.1~3.0 mg·mL-1 (r=0.9995), the precision RSD is less than 3%. Conclusion This method has high sensitivity and good accuracy, which is helpful to improve the quality standard research of PSS and reduce the occurrence of adverse reactions.
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