| 薛亮,墨自营,张之金,等.苯并硒唑酮-多糖衍生物的合成及生物活性研究[J].中国海洋药物,2022,41(3):64-68. |
| 苯并硒唑酮-多糖衍生物的合成及生物活性研究 |
| Study on the synthesis and bioactivities of benzoselenidone-polysaccharide derivatives |
| 投稿时间：2021-05-14 修订日期：2021-08-05 |
| DOI： |
| 中文关键词: 有机硒-多糖衍生物 依布硒 硒多糖 |
| English Keywords:organoselenium-polysaccharide derivatives Ebselen selenium-polysaccharide |
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| 中文摘要: |
| 目的 研究有机硒-多糖衍生物的人工合成方法及其生物活性。方法 以依布硒（Ebselen）的含硒基团为母核，对苯并硒唑酮-多糖衍生物进行化学合成。结果 合成了4种苯并硒唑酮-多糖衍生物，所用多糖有3种为海洋来源糖类，并测定了其中2种硒多糖对4种肿瘤细胞的增殖抑制活性，抑制率均超过80%。为苯并硒唑酮-多糖衍生物的合成及其活性研究提供了参考。 |
| English Summary: |
| Objective The synthesis and biological activities of organoselenium-polysaccharide derivatives. Methods Benzoselenidone-polysaccharide derivatives were synthesized by using the selenium-containing group of Ebselen as parent nucleus. Results Four benzoselenidone-polysaccharide derivatives were synthesized, among them, three polysaccharide moiety derived from marine resource. Two selenium-polysaccharides exibited potent inhibitory on the proliferation against four tumor cell lines with the inhibitory rates over 80%. This study provides reference for the synthesis and bioactivity of benzoselenidone-polysaccharide derivatives. |
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