康永锋,段松,李立,等.海绵共附生真菌抗菌活性次级代谢产物研究进展[J].中国海洋药物,2021,40(5):46-58.
海绵共附生真菌抗菌活性次级代谢产物研究进展
Research progress on secondary metabolites of antibacterial activity of sponge-associated fungi
投稿时间：2020-11-30  修订日期：2021-04-06
DOI：
中文关键词:  海绵共附生真菌  次级代谢产物  抗菌活性
English Keywords:sponge-associated fungi  secondary metabolites  antibacterial activity
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作者单位E-mail
康永锋 上海海洋大学 yfkang@shou.edu.cn 
段松 上海海洋大学  
李立 上海海洋大学  
于豪冰 中国人民解放军海军军医大学  
甘建红* 上海海洋大学 jhgan@shou.edu.cn 
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中文摘要:
      海绵共附生真菌次级代谢产物具有独特的化学结构和显著的生物学活性，是创新药物研发的重要来源。这些次级代谢产物对金黄色葡萄球菌(Staphylococcus aureus)、大肠杆菌(Escherichia coli)、枯草芽孢杆菌(Bacillus subtilis)等多种致病菌株具有潜在的抗菌活性。本文综述了2002—2020年之间经文献报道的85个源自海绵共附生真菌的具有抗菌活性的次级代谢产物，结构类型包括生物碱类、聚酮类、蒽醌类、甾体类、肽类及萜类，旨在为抗菌药物进一步研究提供参考。
English Summary:
      The secondary metabolites from sponge-associated fungi have a unique chemical structure and significant biological activity and are an important source of innovative drug development. These secondary metabolites have potential antibacterial activity against various pathogenic strains such as Staphylococcus aureus, Escherichia coli, and Bacillus subtilis. This article reviews 85 secondary metabolites with antibacterial activity derived from sponge-associated fungi reported from 2002 to 2020. The structure types include alkaloids, polyketones, quinone terpenes, steroids, peptides, etc. This review intends to give a reference for antibacterial drug research.
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