| 安子哲,张朝辉,刘梦阳,等.褐藻来源硫酸岩藻聚糖的化学组成与结构的研究进展[J].中国海洋药物,2021,40(4):50-63. |
| 褐藻来源硫酸岩藻聚糖的化学组成与结构的研究进展 |
| Research advances in chemical composition and structure of fucoidan from brown algae |
| 投稿时间：2020-09-28 修订日期：2020-11-09 |
| DOI： |
| 中文关键词: 褐藻 硫酸岩藻聚糖 化学组成 化学结构 综述 |
| English Keywords:brown algae fucoidan chemical composition chemical structure review |
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| 中文摘要: |
| 褐藻硫酸岩藻聚糖是来源于褐藻的结构复杂的一类海洋硫酸多糖,主要由岩藻糖、半乳糖、甘露糖和葡萄糖醛酸组成,并含有少量的木糖、葡萄糖、鼠李糖、阿拉伯糖和氨基葡萄糖。研究表明,褐藻硫酸岩藻聚糖的主链是由 α (1→3) 或 α (1→3)、α (1→4) 交替连接的硫酸化L-岩藻糖构成,还嵌有半乳糖、葡萄糖醛酸等,而厚叶解曼藻和羊栖菜等褐藻硫酸岩藻聚糖的主链是由1→2甘露糖和1→4葡萄糖醛酸构成二糖重复单元。褐藻硫酸岩藻聚糖的主链上普遍存在岩藻糖、半乳糖、甘露糖或葡萄糖醛酸等寡糖的支链,因此糖链结构复杂。硫酸岩藻聚糖的硫酸根位于L-岩藻糖的C-2、C-3或C-4位,也存在C-2,4双硫取代。目前,褐藻硫酸岩藻聚糖结构的分析技术主要为甲基化法分析、核磁共振、二维核磁共振技术和串联质谱分析技术等。本文对褐藻来源硫酸岩藻聚糖的化学组成和结构以及常用分析技术进行了总结,为褐藻硫酸岩藻聚糖的结构分析以及构效关系研究提供依据。 |
| English Summary: |
| Fucoidans are a class of sulfated, fucose-rich polymers found in brown algae, which have a complex structure and mainly composed of sulfated fucose, galactose, mannose, glucuronic acid and small amount of xylose, glucose, rhamnose, arabinose and glucosamine. Previous studies have demonstrated that fucoidan from brown algae is mainly composed of sulfated L-fucose connected by α (1→3) or alternately connected by α (1→3) and α (1→4) glycosidic bonds and containing galactose and glucuronic acid, etc. However, the main chain of fucoidan from Kjellmaniella crassifolia and Sargassum fusiforme consists of a repeating disaccharide unit of [→4GlcAβ1,2Manα1→]. Fucose, galactose, mannose or glucuronic acid and other oligosaccharides branch are widespread in the main chain of fucoidan. Therefore, the structure of fucoidan is complex. Sulfate groups are mainly located at C-2, C-3 or C-4, and some fucose residues are disulfated at C-2 and C-4. At present, the primary techniques in fucoidan structural analysis include methylation analysis, NMR spectroscopy, two-dimensional NMR spectroscopy and liquid chromatography-tandem mass spectrometry, etc. Here we give an up-to-date review on the chemical composition, construction and common analytical techniques of fucoidan from brown algae. We hope this review would benefit the future studies on the structural analysis and structure-activity relationship research of fucoidan. |
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