| 石竹,李芯蕊,王蕊红,等.SIRT1蛋白与mTOR信号通路作为糖尿病及糖尿病并发症治疗靶点的研究进展[J].中国海洋药物,2020,39(6):74-83. |
| SIRT1蛋白与mTOR信号通路作为糖尿病及糖尿病并发症治疗靶点的研究进展 |
| Research progress of SIRT1 protein and mTOR signaling pathway as targets for the treatment of diabetes and its complications |
| 投稿时间：2020-03-27 修订日期：2020-05-08 |
| DOI： |
| 中文关键词: SIRT1蛋白 mTOR信号通路 糖尿病 |
| English Keywords:SIRT1 protein mTOR signaling pathway diabetes |
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| 中文摘要: |
| 糖尿病是全球最普遍的非传染性疾病之一，并且发病率逐年增加，糖尿病及其并发症已经成为全球关注的公共卫生问题，亟需新的、更有效的治疗药物。特殊的生存环境导致了海洋生物独特的代谢途径，因此从海洋环境中寻找新颖的抗糖尿病药物潜力巨大。糖尿病的发病机制非常复杂，其中SIRT1蛋白以及mTOR信号通路在糖尿病的发病机制中发挥了非常重要的作用。本文主要总结了SIRT1蛋白以及mTOR信号通路对糖尿病的调控作用，以期为抗糖尿病海洋药物的筛选提供新的靶点，加快我国“蓝色药库”的开发 |
| English Summary: |
| Diabetes is one of the most common non-communicable diseases in the world, and its incidence is increasing year by year. Diabetes and its complications have become a global public health problem, so more effective drugs are urgently needed. Marine life is very different from land because of its special living environment, so it is potential to find novel anti-diabetic drugs from the marine environment. The pathogenesis of diabetes is very complicated. Among them, SIRT1 protein and mTOR signaling pathway play important roles in diabetes progression. This article mainly summarizes the roles and mechanisms of SIRT1 protein and mTOR signaling pathway in diabetes and its complications in order to provide new targets for the screening of anti-diabetic marine compounds, accelerating the development of China"s "Blue Drug Bank" project. |
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