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| Sclerotiorin的胺类衍生物的潜在抗病毒活性及其初步构效关系研究（英文） |
| Potential Antiviral Sclerotiorin Amine Derivatives and Their Preliminary Structure-Activity Relationship |
| 投稿时间：2019-05-15 修订日期：2019-05-15 |
| DOI： |
| 中文关键词: 抗病毒活性 Sclerotiorin的胺类衍生物 构效关系 |
| 英文关键词: Antiviral activity, sclerotiorin amine derivatives, structure-activity relationship |
| 基金项目:国家自然科学(U1706210,41606172和41776141)； |
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| 中文摘要: |
| 目的 为了评价天然产物(+)-sclerotiorin及其半合成衍生物的抗病毒活性。方法 通过CPE法评价(+)-Sclerotiorin (1)及其半合成衍生物(2-31)对RSV,EV71,HSV-1,H1N1和Cox-B3的抗病毒活性。结果 化合物3和11显示出对EV71的抗病毒活性,并且具有非常高的选择性指数值(SI值分别为37.8和38.0)。结论 化合物3和11是潜在的抗病毒先导化合物。 |
| 英文摘要: |
| Objective To evaluate antiviral activity of the natural compound, (+)-sclerotiorin and its semisynthetic derivatives. Methods (+)-Sclerotiorin (1) and its semisynthetic derivatives (2–31) were evaluated for their antiviral activities against RSV, EV71, HSV-1, H1N1, and Cox-B3 by the CPE inhibition assay. Results Compounds 3 and 11 showed potent and selective antiviral activity against EV71, and have very high selectivity index values (SI 37.8 and 38.0, respectively) Conclusion Compounds 3 and 11 are potent antiviral candidates. |
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