| 董玉静,张京星,李文利,李花月.深海链霉菌Streptomyces samsunensis中geldanamycin类抗生素的分离纯化（英文）[J].中国海洋药物,2020,39(2):1-10. |
| 深海链霉菌Streptomyces samsunensis中geldanamycin类抗生素的分离纯化（英文） |
| Isolation of geldanamycin antibiotics from deepsea-derived Streptomyces samsunensis |
| 投稿时间：2019-05-06 修订日期：2019-05-06 |
| DOI：10.13400/j.cnki.cjmd.2020.02.001 |
| 中文关键词: 基因组信息，深海链霉菌，多重耐药，抗生素 |
| English Keywords:genomic information deepsea-derived Streptomyces multi-drug resistant antibiotics |
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| 中文摘要: |
| 通过基因组生物信息学分析，从深海来源的Streptomyces samsunensis OUCT16-12中分离得到两个抗生素，分别为geldanamycin（1）和17-O-demethylgeldanamycin（2）。化合物1和2对几种多药耐药（MDR）菌株表现出显着的抗菌活性，最小抑菌浓度（MIC）分别为3.125-12.5μg/ mL和6.25-25μg/ mL而且在化合物1的17-OH处加入甲基增加了抗菌活性。因此，这些化合物有潜力作为有效的抗MDR菌药物候选物。 |
| English Summary: |
| Using genomic bioinformatics analysis, two antibiotics, identified as geldanamycin (1) and 17-O-demethylgeldanamycin (2), were isolated from deepsea-derived Streptomyces samsunensis OUCT16-12. Compounds 1 and 2 exhibited notable antibacterial activities against several multi-drug resistant (MDR) strains with minimum inhibitory concentrations (MICs) ranging from 3.125-12.5 μg/mL and 6.25-25 μg/mL, respectively. Interestingly, the addition of a methyl group at 17-OH of compound 1 increased the antibacterial activity. Therefore, these compounds have the potential to serve as interesting and effective anti-MDR agents. |
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