董玉静,张京星,李文利,李花月.深海链霉菌Streptomyces samsunensis中geldanamycin类抗生素的分离纯化(英文)[J].中国海洋药物,2020,39(2):1-10.
深海链霉菌Streptomyces samsunensis中geldanamycin类抗生素的分离纯化(英文)
Isolation of geldanamycin antibiotics from deepsea-derived Streptomyces samsunensis
投稿时间:2019-05-06  修订日期:2019-05-06
DOI:
中文关键词:  基因组信息,深海链霉菌,多重耐药,抗生素
English Keywords:genomic information  deepsea-derived  Streptomyces  multi-drug resistant  antibiotics
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作者单位
董玉静,张京星,李文利,李花月 中国海洋大学,中国海洋大学,中国海洋大学,中国海岸大学 
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中文摘要:
      通过基因组生物信息学分析,从深海来源的Streptomyces samsunensis OUCT16-12中分离得到两个抗生素,分别为geldanamycin(1)和17-O-demethylgeldanamycin(2)。化合物1和2对几种多药耐药(MDR)菌株表现出显着的抗菌活性,最小抑菌浓度(MIC)分别为3.125-12.5μg/ mL和6.25-25μg/ mL而且在化合物1的17-OH处加入甲基增加了抗菌活性。因此,这些化合物有潜力作为有效的抗MDR菌药物候选物。
English Summary:
      Using genomic bioinformatics analysis, two antibiotics, identified as geldanamycin (1) and 17-O-demethylgeldanamycin (2), were isolated from deepsea-derived Streptomyces samsunensis OUCT16-12. Compounds 1 and 2 exhibited notable antibacterial activities against several multi-drug resistant (MDR) strains with minimum inhibitory concentrations (MICs) ranging from 3.125-12.5 μg/mL and 6.25-25 μg/mL, respectively. Interestingly, the addition of a methyl group at 17-OH of compound 1 increased the antibacterial activity. Therefore, these compounds have the potential to serve as interesting and effective anti-MDR agents.
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