| 高翠翠,张君,马海珍,等.甘油糖醚Myrmekiosides A类似物的合成及初步活性研究[J].中国海洋药物,2019,38(4):1-10. |
| 甘油糖醚Myrmekiosides A类似物的合成及初步活性研究 |
| The synthesis and anti-tumor activity of Myrmekiosides A analogs |
| 投稿时间：2019-03-27 修订日期：2019-05-08 |
| DOI： |
| 中文关键词: 甘油糖醚Myrmekiosides A 类似物 合成 抗肿瘤活性 |
| English Keywords:Myrmekiosides A analogs synthesis anti-tumor activity |
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| 中文摘要: |
| 通过改变天然产物甘油糖醚Myrmekiosides A的甘油骨架上连接的糖基类型和长链烷基,高效合成了5个类似物(Myrmekioside A-1~5)。5个类似物对非小细胞肺癌株A549抑制活性测试发现,甘油糖醚结构中的糖单元类型和烷基长链对抗肿瘤活性均有影响,其中 Myrmekioside A-4具有最好的抑制活性,抑制率为71%。 |
| English Summary: |
| Five analogs (Myrmekioside A-1~5) were designed by changing the type of glycosyl and the long-chain alkyl groups attached to the glycerol skeleton of natural glycolipid Myrmekiosides A, and the target compounds were obtained with high yields. The anti-tumor activities of five analogs against non-small cell lung cancer cell line A549 were evaluated. The results showed that both the type of glycosyl group and the alkyl chain had an effect on the tumor activity. Myrmekioside A-4 demonstrated the best cytotoxic activity against A549 with 71% inhibition. |
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