文章摘要
鲍道洋,胡倩倩,李平林,等.西沙软珊瑚Sarcophyton.sp.共附生青霉菌Penicillium citrinum次级代谢产物和生物活性研究[J].中国海洋药物,2019,38(6):21-24.
西沙软珊瑚Sarcophyton.sp.共附生青霉菌Penicillium citrinum次级代谢产物和生物活性研究
Secondary metabolites and their bioactivities of the fungus penicillium citrinum isolated from the soft coral Sarcophyton.sp.
投稿时间:2019-03-22  修订日期:2019-04-27
DOI:
中文关键词: 青霉菌  次级代谢产物  化学成分  生物活性
英文关键词: penicillium citrinum  Secondary metabolites  chemical constituents  bioactivities
基金项目:国家自然科学基金面上项目(41876161)。
作者单位E-mail
鲍道洋 中国海洋大学海洋药物教育部重点实验室 1004479388@qq.com 
胡倩倩 中国海洋大学海洋药物教育部重点实验室  
李平林 中国海洋大学海洋药物教育部重点实验室  
唐旭利 中国海洋大学化学化工学院  
李国强 中国海洋大学海洋药物教育部重点实验室 liguoqiang@ouc.edu.cn 
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中文摘要:
      目的:对从软珊瑚Sarcophyton.sp.中发现的青霉菌Penicillium citrinum的次级代谢产物进行研究。方法:利用硅胶柱色谱、薄层色谱、Sephadex LH-20、ODS中压色谱、凝胶色谱、半制备HPLC等方法对该菌的次级代谢产物进行了分离纯化;通过NMR、MS等方法,并结合文献对照,鉴定化合物的结构。结果:从青霉菌Penicillium citrinum中一共发现了8个化合物:2,3-dihydrosorbicillin(1)、Citrinin (2)、Penicitol(3)、dimethyl-4,7- dihydroxy-9-oxo-9H-xanthene-3,5-dicarboxylate(4)、Emodin(5)、methyl-2,8- dihydroxy-6-methyl-9-oxo-9H-xanthene-1- dicarboxy(6)、8-hydroxy-6-methyl-9-oxo- 9H-xanthene-1- carboxylate(7)、ergostane(8)。生物活性显示化合物3对HCT-116和Hela细胞株有细胞毒性。
英文摘要:
      Objective To investigatethe secondary metabolites and their bioactivityies of the fungus penicillium citrinum isolated from a soft coral Sarcophyton.sp. Methods the techniques of silica gel column,TLC, SephadexLH-20, ODS medium-pressure chromatography, gel chromatography and semi-preparative HPLC were used to isolate and purify the compounds from the secondary metabolites yield by Penicillium citrinum.The structure of the compounds was identified by NMR, MS and literature comparison. Results eight compounds were isolated from the Penicillium citrinum and identified as 2,3-dihydrosorbicillin(1),Citrinin (2), Penicitol(3),dimethyl-4,7- dihydroxy-9-oxo-9H-xanthene-3,5-dicarboxylate(4)、Emodin(5),methyl-2,8-dihydroxy-6- methyl-9-oxo-9H-xanthene-1-carboxylate(6),8-hydroxy-6-methyl-9-oxo-9H-xanthene-1- carboxylate(7)、ergostane(8). Biological activity showed that compound 3 was cytotoxic to HCT-116 and Hela cell lines.
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