| 宿凡,管培竹,杨金波,等.β-葡聚糖与模式识别受体Dectin-1相互作用研究进展[J].中国海洋药物,2019,38(5):54-60. |
| β-葡聚糖与模式识别受体Dectin-1相互作用研究进展 |
| The progress of interaction between β-glucan and pattern recognition receptor Dectin-1 |
| 投稿时间：2019-03-19 修订日期：2019-04-18 |
| DOI： |
| 中文关键词: β-葡聚糖 结构与活性 病原相关分子模式（PAMP） 模式识别受体（PRR） Dectin-1 |
| English Keywords:β-glucan chemical structure and bioactivity pathogen-associated molecular pattern (PAMP) pattern recognition receptor (PRR) Dectin-1 |
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| 中文摘要: |
| β-葡聚糖是自然界资源最丰富的多糖之一，尤其真菌来源的β-1,3-葡聚糖是结构独特、免疫调节活性好且研究报道最多的葡聚糖。本文对β-葡聚糖的发现、化学结构与生物活性、以及β-1,3-葡聚糖作为病原相关分子模式（PAMP）与其模式识别受体（PRR）Dectin-1之间的相互作用进行了综述，着重论述了不同理化性质的β-葡聚糖对人和鼠来源Dectin-1不同亚型的激活作用，所得结论，为以Dectin-1为靶点抗肿瘤药物的研发提供了参考。 |
| English Summary: |
| β-glucan is the most abundant polysaccharide in the natural resource, especially the fungi β-1,3-glucans, which has unique structure and has been extensively reported for its immune modulatory activities. We summarize the discovery of β-1,3-glucan, its chemical structure and bioactivity, the interactions between β-glucan as a pathogen-associated molecular pattern (PAMP) with its pattern recognition receptor (PRR) Dectin-1, with the emphasis on the activation of different β-glucans on human or mouse Dectin-1 different isoforms. The conclusions obtained provide the references for the research and development of anti-tumor drugs targeting Dectin-1. |
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