| Alzheimer’s disease (AD), one of the most common neurodegenerative diseases among elderly, causes severe economic and social problems in modern society. However, there is no effective drug towards AD. Although existed anti-AD drugs can delay the progress of AD, and mitigate the disease symptom, they are not able to produce the disease-modifying effects. There are a huge number of marine organism which could produce natural products with a variety of pharmacology activities. Some of marine-derived compounds could exert neuroprotective effects, and might be used to treat AD. GV971, a mannooligosaccharide derived from brown algae, has finished phase III clinical trial in China, and might be the only anti-AD drug that closest to the success during the past 10 years. Therefore, this study summarizes the neuroprotective mechanisms of representative marine-derived anti-AD compounds, especially those isolated from marine animals, plants and other organisms, with the aim of providing further support for developing marine-derived anti-AD drugs.