文章摘要
靶向病毒核糖核蛋白的抗流感病毒药物研究进展
Progress in research on anti-influenza virus drugs targeting viral ribonucleoprotein
投稿时间:2019-02-25  修订日期:2019-03-25
DOI:
中文关键词: 流感病毒  核糖核蛋白  新靶点  抗病毒药物  天然产物
英文关键词: Influenza virus  ribonucleoprotein  new target  antiviral drugs  natural product
基金项目:国家自然科学基金项目(81874320, 81741146);国家自然基金-山东省联合基金项目(U1606403, U1706210);山东省自然基金(ZR2017MH013)
作者单位E-mail
俞蕴嘉 海洋药物教育部重点实验室 yuyunjia7963@163.com 
张洋 海洋药物教育部重点实验室  
王伟 海洋药物教育部重点实验室 wwwakin@ouc.edu.cn 
摘要点击次数: 57
全文下载次数: 40
中文摘要:
      流行性感冒病毒所导致的人畜共患病长久以来威胁着人类的健康,但目前可用于临床的抗流感病毒药物十分有限,且逐渐出现了病毒耐药性的问题。因此,研究者们近来致力于探究新型抗流感药物靶点的发现,并期望针对新靶点设计疗效好且不易发生耐药的抗流感病毒药物。流感病毒核糖核蛋白具有不同毒株间保守性高,在病毒复制周期中作用广泛的特点,是设计开发新型抗流感药物的潜在靶点。本文对目前临床使用的抗流感药物靶点、核糖核蛋白的结构与功能及其相关药物的研究进展进行了综述,以期为新型抗流感药物的研发提供参考。
英文摘要:
      The zoonotic disease flu caused by the influenza virus has long threatened human health, but there are very limited anti-influenza drugs available for clinical use, and the problem of virus resistance has gradually emerged. Therefore, Therefore, researchers have recently been working on the discovery of new anti-influenza drug targets, and expect to design novel anti-IAV drugs with good efficacy and low risk of inducing drug resistance. Influenza virus ribonucleoprotein has high conservativeness among different strains and play a wide role in the replication cycle of influenza viruses. Thus, virus ribonucleoprotein can be a potential target for the design and development of novel anti-influenza drugs. This article is aimed to review the the current research progress on the target of anti-IAV drugs in clinical, the structure and function of ribonucleoprotein and related drugs, so as to provide reference for the research and development of novel anti-influenza drugs.
查看全文   查看/发表评论  下载PDF阅读器
关闭