文章摘要
靶向烟碱型乙酰胆碱受体的芋螺毒素研究进展
Advances in the conotoxins targeting nicotinic acetylcholine receptors
投稿时间:2018-06-11  修订日期:2018-11-12
DOI:
中文关键词: 烟碱型乙酰胆碱受体  芋螺毒素  超家族  芋螺多肽  分子探针
英文关键词: nAChRs  conotoxins  superfamily  conopeptides  molecular probes
基金项目:
作者单位
徐婷 中国人民解放军火箭军总医院 
童卫杭 中国人民解放军火箭军总医院 
王军 中国人民解放军火箭军总医院 
杜爱翠 中国人民解放军火箭军总医院 
王硕 中国人民解放军火箭军总医院 
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中文摘要:
      芋螺毒素是由海洋肉食性芋螺所分泌的用于捕杀猎物的高活性生物多肽类毒素,据估计,全世界范围内约含100,000种不同的芋螺毒素,按照保守的信号区可分为A、B2、C、D、O、M、T等27个超家族。不同家族的芋螺毒素能够特异性的靶向各种离子通道和受体,因而成为了具有潜在药用价值的先导化合物和研究神经药理学的分子探针。当前报道的靶向烟碱型乙酰胆碱受体的芋螺毒素来自十个超家族,分别为A、B3、C、D、J、L、S、O1、M和T。本文对这十个超家族中靶向烟碱型乙酰胆碱受体的芋螺毒素的序列、结构及功能进行简要综述。
英文摘要:
      Conotoxins were highly bioactive peptides utilized by marine predatory cone snails (Conus species) to subdue their preys. It was estimated a repertoire of more than 100,000 different conotoxins around the world. According to the highly conserved signal region, conotoxins can be classified into 27 superfamilies: A, B2, C, D, O, M and T-superfamily, et al. Each superfamily of the conotoxins selectively target a specific subtype of ion channels or receptors. Due to their highly pharmacological potency and target selectivity, Conus peptides have developed as potential drug leads or as new research tools in neuroscience field. Currently, conotoxins from ten superfamilies (A, B3, C, D, J, L, S, O1, M and T) have been reported to specifically target nicotinic acetylcholine receptors (nAChRs). This review aims to give a brief summary of the studies on sequence characters, structures and functions of the conotoxins that specifically target nAChRs.
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