齐月璇,张雪晴,邵长伦.一株六放珊瑚来源真菌Exserohilum sp.中活性天然产物研究(英文)[J].中国海洋药物,2018,37(6):29-32.
一株六放珊瑚来源真菌Exserohilum sp.中活性天然产物研究(英文)
Research on bioactive natural products from the zoanthid-derived fungus Exserohilum sp.
投稿时间:2018-05-25  修订日期:2018-12-17
DOI:
中文关键词:  六放珊瑚来源的真菌,Exserohilum sp.,抗真菌活性,抗污损活性
English Keywords:zoanthid-derived fungus, Exserohilum sp., antibactirial activity, antifouling activity
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作者单位
齐月璇,张雪晴,邵长伦 中国海洋大学 海洋药物教育部重点实验室,中国海洋大学 海洋药物教育部重点实验室,中国海洋大学 海洋药物教育部重点实验室,中国海洋大学 海洋药物教育部重点实验室 
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中文摘要:
      目的 研究六放珊瑚来源的真菌Exserohilum sp.中活性天然产物。方法 综合运用硅胶柱层析、Sephadex LH-20凝胶柱层析和半制备型HPLC等分析和分离技术分离纯化化合物,利用核磁、质谱等现代波谱分析方法对化合物进行结构鉴定,以致病真菌、细菌和海洋污损细菌为活性模型对化合物进行活性评价。结果从Exserohilum sp.中分离鉴定了4个天然产物 (1–4),化合物3对致病真菌Candida albicans和海洋污损细菌Pseudomonas aeruginosa显示中等抑制活性,MIC 分别为16.33 和32.65 μg/mL。结论 从海洋来源的真菌中分离获得具有生物活性的天然产物1–4,化合物3 对致病真菌和海洋污损细菌显示中等抑制活性。
English Summary:
      Objective To isolate bioactive natural products from the zoanthid-derived fungus Exserohilum sp. Methods Silica gel column chromatography (CC), Sephadex LH-20 gel CC, and semi-preparative HPLC were used to isolate and purify the products. NMR and mass spectrum technology were used to confirm the chemical structures of natural products. These natural products were tested for their activity against pathogenic fungi, bacteria, and marine fouling bacteria. Results Four natural compounds (1–4) were isolated from the fungus Exserohilum sp. Compound 3 showed weak antimicrobial activity against the fungus Candida albicans ((MIC = 16.33 μg/mL) and marine fouling bacteria Pseudomonas aeruginosa (MIC = 32.65 μg/mL). Conclusions Bioactive natural products were isolated from marine-derived fungus, with 3 displayed antimicrobial activities against pathogenic fungi and marine fouling bacteria.
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