| 马倩芸,江涛,于日磊.烟碱乙酰胆碱受体结构的研究进展[J].中国海洋药物,2018,37(2):97-102. |
| 烟碱乙酰胆碱受体结构的研究进展 |
| Progress in the Structural Research of Nicotinic Acetylcholine Receptors |
| 投稿时间：2017-05-10 修订日期：2017-06-13 |
| DOI： |
| 中文关键词: 烟碱乙酰胆碱受体 离子通道受体 五聚体。 |
| English Keywords:Nicotinic acetylcholine receptor ligand-gated ion channels pentamer. |
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| 中文摘要: |
| 烟碱型乙酰胆碱受体（nAChR）是离子通道型受体，属于Cys-loop受体的超级家族，通过配体门控离子通道介导许多生理活动，是治疗精神类疾病的重要靶点。nAChR包括肌肉型和神经型两种。nAChR是由五个亚基组成的具有中心孔道的五聚体，本文简要介绍了近年来烟碱乙酰胆碱受体结构的研究进展。 |
| English Summary: |
| Nicotinic acetylcholine receptor (nAChR)belongs to the Cys-loop receptor family of ligand-gated ion channels mediating many physiological activities in the nervous system, and are important drug targets for treatment of neurological diseases. It contains both the muscle-type nAchR and the neuron-type nAchR. And nAChR is a pentamer consisting of five subunits with a central channel. The recent advances of the structure of nicotinic acetylcholine receptor have been introduced in this article. |
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