张琳,贾彦来,房耀维,等.西沙群岛来源真菌Pestalotiopsis sp.中脑苷脂类化合物及其生物活性研究[J].中国海洋药物,2017,36(2):35-39.
西沙群岛来源真菌Pestalotiopsis sp.中脑苷脂类化合物及其生物活性研究
The chemical structures and bioactivities of cerebrosides isolated from the marine-derived fungus Pestalotiopsis sp. collected from Xisha Islands
投稿时间:2016-08-24  修订日期:2016-09-02
DOI:
中文关键词:  Cerebroside A  (4E,8E)-N-D-2′-hydroxypalmitoyl-1-O-β-D-glycopyranosyl-9-methyl-4,8-sphingadienine  抗菌活性  抗病毒活性
English Keywords:Cerebroside A  (4E,8E)-N-D-2′-hydroxypalmitoyl-1-O-β-D-glycopyranosyl-9-methyl-4,8-sphingadienine  antimicrobial activity  antiviral activity
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作者单位E-mail
张琳 中国海洋大学 海洋药物教育部重点实验室 1304361368@qq.com 
贾彦来 山东省产品质量检验研究院  
房耀维 中国海洋大学 海洋药物教育部重点实验室  
邵长伦* 中国海洋大学 海洋药物教育部重点实验室 shaochanglun@ouc.edu.cn 
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中文摘要:
      目的 研究中国南海西沙群岛来源真菌Pestalotiopsis sp.7-6中的活性次级代谢产物的化学结构及其生物活性。方法 利用现代波谱方法,鉴定脑苷脂类化合物cerebroside A (1)和(4E,8E)-N-D-2′-hydroxypalmitoyl-1-O-β-D –glycopyranosyl -9-methyl-4,8-sphingadienine (2)的化学结构;利用抗菌和抗病毒活性模型对其进行生物活性评价。结果 化合物1对痢疾志贺氏菌 (Shigellad ysenteriae) 显示一定的抗菌活性(MIC = 50 μM);化合物2对单纯疱疹病毒 (HSV-1) 和肠道病毒71 (EV71) 有较好的抗病毒活性。结论 从西沙群岛来源真菌Pestalotiopsis sp.7-6中分离获得两个具有抗菌和抗病毒活性的脑苷脂类化合物。
English Summary:
      Objective To study the chemical structures and bioactivities of a marine-derived fungus Pestalotiopsis sp.7-6 isolated from Xisha Islands collected from the South China Sea. Methods The chemical structures of compounds 1 and 2 were identified by modern spectrum analysis method. The antibacterial and antiviral activities were also evaluated by using their evaluation models. Results Compound 1 exhibited mild antibacterial activity against Shigellad ysenteriae with the MIC value of 50 μM. Compound 2 exhibited good antimicrobial activity. Conclusion Two cerebrosides, with antibacterial and antiviral activities, were isolated from marine-derived fungus Pestalotiopsis sp.7-6.
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