| 郑彩娟,黄国雷,刘雨心,等.红树植物尖瓣海莲（Brguiera sexangula var. rhynchopetala）化学成分研究[J].中国海洋药物,2017,36(1):7-13. |
| 红树植物尖瓣海莲（Brguiera sexangula var. rhynchopetala）化学成分研究 |
| Study on the chemical constituents of Brguiera sexangula var. rhynchopetala |
| 投稿时间：2016-05-26 修订日期：2016-09-08 |
| DOI： |
| 中文关键词: 尖瓣海莲 化学成分 结构鉴定 抗菌活性 |
| English Keywords:Brguiera sexangula var. rhynchopetala chemical constituents structural identification antibacterial activity |
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| 目的 对红树植物尖瓣海莲（Brguiera sexangula var. rhynchopetala）化学成分及抗菌活性进行研究。方法 采用活性追踪分离的方法，利用硅胶柱层析、Sephadex LH-20 凝胶柱层析和半制备 HPLC 等手段对尖瓣海莲茎的化学成分进行了分离纯化；通过NMR, MS 等波谱方法并与文献对照，确定化合物的结构；利用微量稀释法评价化合物的抗菌活性。结果 从红树植物尖瓣海莲（Brguiera sexangula var. rhynchopetala）茎的石油醚提取物中分离鉴定了 6 个单体化合物，分别为: methylent-16β,17-dihydroxy-9(11)-kauren-19-oate (1), ceriopsin E (2), ent-kaur-16-en-13-hydroxy-19-al (3), 4α,5S,8α,9α,10S,13S-ent-17-hydroxy-16-oxobeyeran-19-al (4), 17-hydroxy-16-oxobeyer-9(11)-en-19-al (5) 和 4'-hydroxy-3'-methoxyphenol-β-D-[6-O-(4"-hydroxy-3",5"-dimeth-oxylbenzoate)]-glucopyranoside (6)。结论 化合物 2, 3 和 6 为首次从该植物中分离得到。酚苷类化合物 6 对溶藻弧菌(Vibrio alginolyticus) 和白色葡萄球菌 (Staphylococcus albus) 显示较强的抑制活性。 |
| English Summary: |
| Objective To investigate the chemical constituents and their bioactivities of Brguiera sexangula var. rhynchopetala. Methods Under the guidance of bioassay, column chromatography on silica gel and Sephadex LH-20, and semi-preparative HPLC were used to isolate and purify the chemical constituents from the stems of B. sexangula var. rhynchopetala. The structures of the isolated compounds were identified by spectroscopic analysis including NMR and MS, and by comparison with the data of literature. The isolated compounds were evaluated with antibacteria activities. Results Six compounds were isolated from the stems of B. sexangula var. rhynchopetala, and their structures were identified as methylent-16β,17-dihydroxy-9(11)-kauren-19-oate (1), ceriopsin E (2), ent-kaur-16-en-13-hydroxy-19-al (3), 4α,5S,8α,9α,10S,13S-ent-17-hydroxy-16-oxobeyeran-19-al (4), 17-hydroxy-16-oxobeyer-9(11)-en-19-al (5) and 4'-hydroxy-3'-methoxyphenol-β-D-[6-O-(4"-hydroxy-3",5"-dimeth-oxylbenzoate)]-glucopyranoside (6). Conclusion Compounds 2, 3 and 6 were isolated from B. sexangula var. rhynchopetala. for the first time. The phenolic glycoside compound 6 exhibited potent antibacterial activity against Vibrio alginolyticus and Staphylococcus albus. |
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