文章摘要
一株渤海来源真菌Pleosporales sp.中嗜氮酮类化合物及其生物活性
Bioactive azaphilones from a marine-derived Pleosporales sp. fungus collected from the Bo Sea
投稿时间:2016-01-10  修订日期:2016-01-14
DOI:
中文关键词: Pleosporales  嗜氮酮类化合物  抗真菌活性
英文关键词: Pleosporales  azaphilone  antifungal activity
基金项目:保定市科技支撑项目 (15ZN020); 河北大学人才引进计划项目
作者单位E-mail
曹飞 河北大学药学院 caofei542927001@163.com 
张冰洋 河北大学药学院  
李婉 河北大学药学院  
朱华结 河北大学药学院 hjzhu@mail.kib.ac.cn 
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中文摘要:
      目的 对一株渤海来源真菌Pleosporales sp.中嗜氮酮类化合物进行分离鉴定,并探讨其生物活性。方法 利用硅胶柱层析和高效液相色谱等分离手段对化合物进行分离和纯化;运用NMR和MS等现代波谱方法,并结合相关文献,对化合物的结构进行鉴定;运用抗真菌活性模型对化合物的生物活性进行评价。结果 从该真菌中分离获得了6个嗜氮酮类化合物isochromophilone I, VI, IX (1–3), (+)-sclerotiorin (4), 5-chloroisorotiorin (5), hypocrellone A (6)。化合物1–6对三株农业致病真菌Thielaviopsis paradoxa, Pestalotia calabae, 和Glorosprium musarum均显示出中等强度的抑制活性。结论 化合物1–6均为首次从Pleosporales属真菌中分离得到,具有作为抗农业致病真菌药的研究价值。
英文摘要:
      Objective To investigate azaphilones from a marine-derived Pleosporales sp. fungus collected from the Bo Sea. Methods Azaphilones were separated and purified by column chromatography on Silica gel and octadecylsilyl, and semi-preparative HPLC. Their structures were elucidated by extensive NMR and MS spectroscopic data, and by comparison with the data of literature. Antifungal activities of these compounds were also evaluated. Results Four azaphilones, isochromophilone I, VI, IX (1–3), (+)-sclerotiorin (4), 5-chloroisorotiorin (5), hypocrellone A (6), were obtained from the fungus Pleosporales sp. Compounds 1–6 showed moderate antifungal activities against three plant pathogenic fungi, including Thielaviopsis paradoxa, Pestalotia calabae, and Glorosprium musarum. Conclusion All of the isolated compounds were obtained from the fungus of the genus Pleosporales for the first time. Azaphilones showed pharmaceutical potential as antifungal agents.
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