高捷,冯瑜,黄磊,等.海洋放线菌Rubrobacter radiotolerans的活性成分研究[J].中国海洋药物,2016,35(2):13-17.
海洋放线菌Rubrobacter radiotolerans的活性成分研究
Studies on the biological Constituents of Marine actinomycetes Rubrobacter radiotolerans.
投稿时间：2015-06-09  修订日期：2015-06-23
DOI：
中文关键词:  海洋放线菌  Rubrobacter radiotolerans  化学成分  细胞毒活性
English Keywords:Marine actinomycetes, Rubrobacter radiotolerans  Chemical constituents  cytotoxicity
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作者单位E-mail
高捷 南通大学附属医院 yglxll@163.com 
冯瑜 重庆市涪陵区义和镇卫生院  
黄磊 南通大学药学院  
杨敏 南通大学药学院  
李建林* 南通大学药学院 jianlinli1980@163.com 
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中文摘要:
      目的：研究海洋共附生放线菌的化学成分。方法：采用中低压液相色谱、制备高效液相色谱法及重结晶等方法对放线菌提取物进行分离纯化,根据波谱数据结合理化性质解析所得化合物的结构,并对分离得到的单体化合物进行了细胞毒活性的筛选。结果：从放线菌 Rubrobacter radiotolerans 的醋酸乙酯萃取部分分离得到7个化合物,其结构分别鉴定为[3-[2-[(indol-3-yl)methyl]indol-3-yl]methylindole, 1]、[bis[2-[(indol-3-yl)methyl]
English Summary:
      Objective: To study the biological constituents of marine derived actinomycetes Rubrobacter radiotolerans. Methods: Constituents were separated and repeatedly purified by means of column chromatography on flash column, sephadex LH-20 and preparative HPLC, etc. Their structures were elicidated by spectral analysis. Results: Seven compounds were obtained from the ethyl acetate extracts, their structures were elucidated as: [3-[2-[(indol-3-yl)methyl]indol-3-yl]methylindole, 1]、 [bis[2-[(indol-3-yl)methyl
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