| 贾彦来,管菲菲,马洁,等.吲哚生物碱brevianamide A的核磁归属,单晶结构及其生物活性研究[J].中国海洋药物,2016,35(1):35-38. |
| 吲哚生物碱brevianamide A的核磁归属,单晶结构及其生物活性研究 |
| The NMR Assignments, Crystal Structure and Bioactivities of Indole Alkaloid Brevianamide A |
| 投稿时间：2015-05-18 修订日期：2015-05-22 |
| DOI： |
| 中文关键词: brevianamide A卤虫致死活性 X-ray |
| English Keywords:brevianamide A lethal activity of brine shrimp X-ray |
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| 中文摘要: |
| 目的 研究海洋真菌来源化合物brevianamide A的化学结构及其生物活性。方法 利用现代波谱解析方法和X-ray单晶技术,对brevianamide A的化学结构进行研究；利用抗菌、卤虫致死和抗病毒活性模型对其生物活性进行评价。结果 首次对brevianamide A单晶数据进行报道,并首次对其核磁数据进行了详细归属；卤虫致死活性表明,brevianamide A具有微弱的卤虫致死活性。结论Brevianamide A的单晶数据、核磁归属数据以及活性数据对今后系统研究brevianamide A类化合物具有参考价值。 |
| English Summary: |
| Objective To study the chemical structure and bioactivity of brevianamide A isolated from a marine-derived fungus. Methods The chemical structure of brevianamide A was studied by using the modern spectrum analysis method amd X-ray crystallographic techniques. The biological activities including antimicrobial activity, lethal activity of brine shrimp, and antiviral activity, were also evaluated by using their evaluation model. Results The single-crystal data of brevianamide A was reported for the first time. The NMR data of brevianamide A were firstly assigned in detail. The lethal activity of brine shrimp results indicated that brevianamide A exhibited weak lethal activity. Conclusion the data of single-crystal, detailed NMR assignment, and bioactivity possessed reference value for the systematic study of brevianamide A and its analogues in the future. |
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