| 梁晓彦,曹飞,王长云.中国南海刺柳珊瑚 Echinogorgia rebekka 中倍半萜氢醌糖苷类化合物及其生物活性△[J].中国海洋药物,2016,35(2):81-86. |
| 中国南海刺柳珊瑚 Echinogorgia rebekka 中倍半萜氢醌糖苷类化合物及其生物活性△ |
| Isolation, identification and bioactivities of farnesylhydroquinone glycosides from the South China Seagorgonian Echinogorgia rebekka |
| 投稿时间：2015-04-29 修订日期：2015-05-14 |
| DOI： |
| 中文关键词: 柳珊瑚 Echinogorgia rebekka 倍半萜氢醌糖苷类化合物 抗菌活性 |
| English Keywords:gorgonian Echinogorgia rebekka farnesylhydroquinone glycosides antibacterial activity |
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| 中文摘要: |
| 目的 对中国南海刺柳珊瑚 Echinogorgia rebekka 中倍半萜氢醌糖苷类化合物进行分离鉴定,并测定其生物活性。方法 运用正反相硅胶柱层析和半制备高效液相色谱等分离手段对化合物进行分离和纯化；运用 NMR 和 MS 等现代波谱方法,并结合相关文献,对化合物的结构进行鉴定；运用细胞毒活性和抗菌活性模型对化合物的生物活性进行评价。结果 从该种柳珊瑚中分离获得了 4 个倍半萜氢醌糖苷类化合物 euplexides A–D (1–4)。化合物 1–4 对肿瘤细胞 HeLa, P388和 A549均显示出中等强度的抑制活性，化合物 2 对恶臭假单胞菌 Pseudomonas putida (MIC = 0.78 μM) 和巴西诺卡菌 Nocardia brasiliensis (MIC = 0.78 μM) 的抑制活性与阳性药环丙沙星相当。结论 化合物 1–4 均为首次从 Echinogorgia 属柳珊瑚中分离得到,具有作为抗菌药的研究价值。 |
| English Summary: |
| Objective To investigate the farnesylhydroquinone glycosides from the gorgonian Echinogorgia rebekka collected from the South China Sea. Methods Farnesylhydroquinone glycosides were separated and purified by column chromatography on Silica gel and octadecylsilyl, and semi-preparative HPLC. Their structures were elucidated by extensive NMR and MS spectroscopic data, and by comparison with the data of literature. The bioactivities of these compounds including antibacterial and cytotoxic activities were also evaluated. Results Four farnesylhydroquinone glycosides, euplexides A–D (1–4), were obtained from gorgonian E. rebekka. Euplexide B (2) exhibited promising antibacterial activity against Pseudomonas putida (MIC = 0.78 μM) and Nocardia brasiliensis (MIC = 0.78 μM), which were almost equivalent to those of the positive control ciprofloxacin. Furthermore, compounds 1–4 showed moderate cytotoxic activity against the tumor cell lines of HeLa, P388, and A549. Conclusion All of the isolated compounds were obtained from the gorgonian of the genus Echinogorgia for the first time. Farnesylhydroquinone glycosides showed pharmaceutical potential as antibacterial agents. |
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