| 邹雪,李平林,李国强.西沙短指软珊瑚Sinularia sp.化学成分研究△[J].中国海洋药物,2015,34(6):83-85. |
| 西沙短指软珊瑚Sinularia sp.化学成分研究△ |
| Study on the Chemical Constitutents of soft coral Sinularia sp. |
| 投稿时间：2015-03-30 修订日期：2015-04-29 |
| DOI： |
| 中文关键词: Sinularia sp. 化学成分 甾醇 环戊烯酮 |
| English Keywords:Sinularia sp. chemical constituents sterols cyclopentenone |
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| 中文摘要: |
| 目的研究中国南海西沙群岛短指软珊瑚Sinularia sp.的化学成分。方法 利用薄层色谱,凝胶柱层析,Sephadex LH-20柱层析, MHPLC, HPLC等常规化学分离手段对该属化学成分进行分离纯化；借助NMR、MS等方法,并对照文献,鉴定其次级代谢产物的结构。结果 从短指软珊瑚的甲醇氯仿提取物中,分离鉴定了5个甾醇类化合物：Subergorgol I (1)、9,11-开环-24-亚甲基-5-胆甾-7-烯-3β,6α,11-三羟基-9酮 (2)、7α-hydroxy-crassarosterol A (3)、(22E)-胆甾-7,22-二烯-3β,5α,6β-三醇 (4)、24-亚甲基胆甾醇 (5)。4个环戊烯酮衍生物：Suberosanone B (6)、Suberosanone A (7)、Hydroxydihydrobovolide (8)、Sinularone C (9)。 |
| English Summary: |
| Abstrect: Objective To investigate the chemical constituents of Sinularia sp..Methods Thecompounds were isolated and purified by TLC, silica gel column, SephadexLH-20 column chromatography, MHPLC and HPLC. Their chemical structures were identified by NMR、MS, and comparison with the data of literatures. Results From the CH3OH/CH2Cl2 soluble extract of Sinularia sp., nine compounds were isolated and their structures were determinedas Subergorgol I (1), 9,11-seco-24-methylene-3β,6α,11-trihydroxy-5α-cholest-7-en-9-one (2),7α-hydroxy-crassarosterol A (3), cholesta-7,22E-diene-3β,5α,6β-triol (4), 24-methylene-cholesterol (5), Suberosanone B (6)、Suberosanone A (7)、Hydroxydihydrobovolide (8)、Sinularone C (9). |
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