| 江明明,唐旭利,李国强,等.西沙短指软珊瑚Sinularia cf. molesta化学成分研究△[J].中国海洋药物,2016,35(3):76-80. |
| 西沙短指软珊瑚Sinularia cf. molesta化学成分研究△ |
| Study on chemical constituents of the Xisha soft coral Sinularia cf. molesta |
| 投稿时间：2015-03-30 修订日期：2015-04-13 |
| DOI： |
| 中文关键词: 短指软珊瑚 化学成分 结构鉴定 |
| English Keywords:Sinularia cf. molesta chemical constituents structural identification |
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| 中文摘要: |
| 目的 研究西沙短指软珊瑚Sinularia cf. molesta的化学成分。方法 利用薄层色谱、硅胶色谱、Sephadex LH-20凝胶色谱、MPLC、HPLC等方法对化学成分进行分离纯化；通过NMR、MS等方法,并结合文献,鉴定化合物的结构。结果 从短指软珊瑚的甲醇粗提物中,分离鉴定了8个单体化合物：(5"Z)-5-(2", 6"-二甲基癸烷-5", 7"-二烯)呋喃-3-羧酸 (1), Norcembrene (2), Norcembrene E (3),(1R, 3S, 4S, 7E, 11E)-3, 4-环氧西松烷-7, 11, 15-三烯 (4), (3E, 7Z, 11Z)-西松烷-2-羰基-3, 7, 11, 15-四烯 (5), clavirolides D (6),β-谷甾醇 (7), 3β-羟基-24-亚甲基胆甾-5-烯-7-酮 (8)。结论 所有化合物(1-8)均为首次从该种分离得到,化合物(5, 6)为第一次从Sinularia属中分离得到。 |
| English Summary: |
| Objective To study the chemical constituents of the soft coral Sinularia cf. molesta. Methods The compounds were isolated by TLC, silica gel, Sephadex LH-20, MPLC and HPLC methods, and their structures were determined by spectroscopic analysis including NMR and MS, and comparison with the data of literatures. Results From the methanol extracts of S. cf. molesta, eight compounds were isolated and identified as (5"Z)-5-(2", 6"-Dirnethylocta-5", 7"-dienyl)furan-3-carboxylic acid (1), Norcembrene (2), Norcembrene E (3), (1R, 3S, 4S, 7E, 11E)-3, 4-epoxycembranoid-7, 11, 15- triene (4), (3E, 7Z, 11Z)- cembranoid-2-one-3, 7, 11, 15-tetraen (5), clavirolides D (6), β-sitosterol (7), 3β-hydroxy-24-mthylenecholest-5-en-7-one (8) . Conclusion All compounds were isolated from this soft coral for the first time, compounds(5, 6) were firstly isolated from Sinularia sp. |
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