文章摘要
海麒舒肝治疗宫颈人乳头瘤病毒感染的疗效及安全性观察
Curative effect and safety of Haiqishugan for treatment of Human Papilloma Virus (HPV) infection of cervix
投稿时间:2015-03-13  修订日期:2015-04-07
DOI:
中文关键词: 海麒舒肝  宫颈  HPV感染  疗效
英文关键词: Haiqishugan  Cervical Human Papilloma Virus  curative effect
基金项目:国家自然科学基金-山东省政府联合资助目(U1406402)资助
作者单位E-mail
冉雪梦 青岛大学医学院附属海慈医院 lilyranxm@163.com 
郭新华 青岛大学附属医院 lilyranxm@163.com 
王世欣 中国海洋大学医药学院  
李春霞 中国海洋大学医药学院  
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中文摘要:
      目的 观察海洋药物海麒舒肝治疗宫颈高危型人乳头瘤病毒感染(HR-HPV)的临床疗效。方法 选择宫颈高危型HPV感染者76例,分为观察组(海麒舒肝)39例和对照组(辛复宁)37例,采用杂交捕获二代(HCⅡ)检测HR-HPV病毒载量。用药3个和6个月经周期后,观察两组治疗前后宫颈糜烂的改善情况及HCⅡ值的变化情况。结果 治疗3个月和6个月后患者的宫颈糜烂均有改善,两组比较无明显差异(P>0.05),使用海麒舒肝后患者均无不良反应;用药3个月后,两组降低HR-HPV病毒载量的总有效率和转阴率比较,无明显差异(P>0.05);用药6个月后,观察组降低HR-HPV病毒载量总有效率(87.2%)高于对照组(62.2%)(P<0.05),观察组对于HR-HPV转阴率(53.8%)亦高于对照组(24.3%)(P<0.05)。 结论 初步证实海麒舒肝可以明显降低宫颈高危型HPV病毒载量,改善宫颈临床症状,对于治疗宫颈HPV感染的疗效确切,无不良反应。
英文摘要:
      objective To observe the efficacy and safety of Haiqishugan for treatment of High-risk human papilloma virus (HR-HPV) infection of cervix. Methods 76 cases of patients with cervical HPV infection were selected and divided into observation group and control group. The patients in observation group were given Haiqishugan, while patients in control group were given XINfuning. The HPV viral load was detected with Hybrid Capture Ⅱ (HCⅡ). The clinical curative effect and drug adverse reactions of patients in both groups were observed and compared after 3 and 6 months medication. Results After treatment the cure rate of cervical erosion had been improved both in the two groups with no significantly difference between them. No adverse reactions had been found in observation group. After 3 months medication the total effective rate of reducing HPV viral load and the HPV negative rate had no significant difference between the observation group and the control group. After 6 months medication the total effective rate of reducing HPV viral load (87.2%) in observation group was significantly higher than that in control group (62.2%). The HPV negative rate (53.8%) in observation group was significantly higher than that in control group (24.3%). Conclusion Through the research it has been verified that Haiqishugan can obviously reduce HPV viral load, better than XINfuning. So Haiqishugan has reliable curative effect on cervical HPV infection without any adverse reaction.
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