| .藻蓝蛋白对2型糖尿病大鼠肝脏和胰岛细胞凋亡影响的研究[J].中国海洋药物,2010,29(2):. |
| 藻蓝蛋白对2型糖尿病大鼠肝脏和胰岛细胞凋亡影响的研究 |
| Effect of phycocyanin on the apoptosis of liver and islet in rats with type 2 diabetic mellitus |
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| DOI： |
| 中文关键词: 藻蓝蛋白 糖尿病 形态结构 细胞凋亡 肝脏 胰岛 |
| English Keywords:phycocyanin diabetes mellitus morphosis apoptosis liver islet |
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| 中文摘要: |
| 目的研究藻蓝蛋白对2型糖尿病大鼠肝脏和胰岛形态结构和细胞凋亡的影响。方法健康雄性Wistar大鼠32只,高糖高脂饲料喂养联合小剂量链脲佐菌素(STZ)腹腔注射建立2型糖尿病大鼠模型,藻蓝蛋白灌胃治疗,组织病理学技术观察肝脏和胰岛细胞的形态结构,用原位末端标记法(Tunel法)检测肝细胞和胰岛细胞凋亡。结果模型组大鼠肝组织结构紊乱,中央静脉扩张,肝细胞肿胀,颗粒变性和脂肪变性;胰岛萎缩、结构模糊,细胞数目减少、排列紊乱,胞浆肿胀、空泡变性等;两个组织中凋亡阳性细胞较正常组明显增多(P<0.05);藻蓝蛋白组肝脏组织和胰岛细胞形态结构较清晰,正常细胞数目增多、排列较规则,肿胀和变性细胞较少,凋亡阳性细胞较模型组显著减少(P<0.05)。结论藻蓝蛋白可抑制糖尿病大鼠肝脏和胰岛细胞凋亡,发挥一定的保护作用。 |
| English Summary: |
| Objective To investigate the effect of phycocyanin on the morphosis and apoptosis of liver and islet cells in rats with type 2 diabetic disease.Methods Type 2 diabetes mellitus models were induced by high sugar and fat diet and low dose intraperitoneal injection of streptozotocin(STZ) in 32 healthy male Wistar rats,and treated with phycocyanin by intragastric administration.The morphosis of liver and islet cells were observed by histopathological technique and the apoptosis of liver and islet cells were det... |
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