| .ZnS-壳聚糖海藻酸钠包裹布洛芬纳米微球的制备和性能研究[J].中国海洋药物,2010,29(2):. |
| ZnS-壳聚糖海藻酸钠包裹布洛芬纳米微球的制备和性能研究 |
| Study on the preparation and characteristic of Zns-chitosan sodium alginate ibuprofen nanomicrosphere |
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| 中文关键词: 硫化锌 壳聚糖 缓控释 纳米微球 |
| English Keywords:ZnS chitosan sustained and controlled release nanomicrospheres. |
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| 中文摘要: |
| 目的以壳聚糖-海藻酸钠为基质材料,掺杂入纳米ZnS包裹非甾体抗炎药物布洛芬,制备缓、控释性能优异的载药纳米微球;为研发四代新剂型打下基础。方法利用复凝聚法,通过调整添加基质材料速度、反应温度、搅拌速度等,制备含ZnS的壳聚糖海藻酸钠布洛芬纳米微球,透射电镜观察纳米微球的形态,测试纳米微球的载药量与包封率,拟肠液条件下测试所致纳米微球的释放特性。结果含ZnS壳聚糖海藻酸钠布洛芬纳米载药微球的粒径约为80~100nm,载药量为40.2%药物包封率78.2%,ZnS粒径3nm。在水溶液、0.9%NaCl和磷酸盐缓冲液中的吸水膨胀程度小于不含ZnS的载药纳米微球;体外拟肠条件溶出表明含ZnS的载药纳米微球具有良好的缓控释性能,药代动力学特征为被动扩散。结论掺入了ZnS的壳聚糖海藻酸钠布洛芬纳米微球,形状圆整,包封率理想,具有良好的缓控释性能。 |
| English Summary: |
| Objective The chitosan-sodium alginate was used as the matrix material,and intermingled with nanometer ZnS Ibuprofen which was encapsuled by nanometer ZnS,to prepare nanomicrosphere with good sustained and controlled release properties.The basis for the novel fourth generation dosage-forms would be built.Methods By using the double coacervation method,through the adjustment of the matrix material,reaction temperature and stir rate,Zns-chitosan sodium alginate Ibuprofen nanomicrosphere was prepared.The confi... |
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