江红;程元荣;郑卫;.海洋碳样小单孢菌产生的大豆黄素和染料木素(英文)[J].中国海洋药物,2007,26(1):8-12.
海洋碳样小单孢菌产生的大豆黄素和染料木素(英文)
Daidzein and Genistein produced by a marine Micromonospora carbonacea FIM 02-635
  修订日期:2006-06-02
DOI:
中文关键词:  小单孢菌属  免疫抑制  异黄酮
English Keywords:Micromonospora  immunosuppressive  isoflavones
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作者单位
江红;程元荣;郑卫; 福建省微生物研究所, 福建医科大学, 
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中文摘要:
      目的研究海洋微生物FIM02—635产生的活性次级代谢产物。方法对产生菌进行分类鉴定。发酵液用有机溶媒提取具有免疫抑制活性的化合物,采用硅胶柱层析及高速逆流色谱的分离方法,提取纯化到2个化合物FW63511和FW63512,通过理化性质测定和光谱学测定分析2个化合物的结构并对这两个化合物进行体外生物活性测定。结果与结论产生菌定名为碳样小单孢菌FIM02—635。FW63511和FW63512分别与异黄酮大豆黄素和染料木素同质,它们具有免疫抑制和抗肿瘤活性,但没有抗菌活性。
English Summary:
      Objective To study the active secondary metabolites from marine microorganism FIM02-635. Methods The producing strain was identified by taxonomical and phylogenetic studies. Two compounds FW63511 and FW63512 with immunosuppressive activities were extracted by organic solvents from the culture broth and purified by silica gel column chromatography and high speed counter current chromatography. The structures of the two compounds were determined by physico-chemical properties and spectral analyses, the biological activities were assayed in vitro. Results and Conclusion The producing strain was named as Micromonospora carbonacea FIM 02-635. Two compounds FW63511 and FW63512 were determined to be isoflavone Daidzein and Genistein, respectively, showed immunosuppressive and antitumor activities, but not antimicrobial activities.
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