| .二十二碳六烯酸(DHA)复合物对胃腺癌细胞内H-Ras和p16 mRNA含量的影响[J].中国海洋药物,2006,25(3):40-42. |
| 二十二碳六烯酸(DHA)复合物对胃腺癌细胞内H-Ras和p16 mRNA含量的影响 |
| Effects of docosahexaenoic acid (DHA) compound on H-Ras and p16 mRNA transcription in gastric adenocarcinoma |
| 投稿时间：2005-04-22 |
| DOI： |
| 中文关键词: 二十二碳六烯酸,细胞凋亡,H-Ras,p16 |
| English Keywords:docosahexaenoic acid(DHA),apoptosis,H-Ras,p16 |
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| 中文摘要: |
| 目的研究DHA复合物抗肿瘤作用机理。方法用RT-PCR法研究DHA复合物对胃腺癌细胞内H-Ras和p16mRNA含量的影响。结果与阴性对照组相比,DHA复合物使胃腺癌细胞内H-RasmRNA含量明显降低(P<0.05),p16mRNA含量明显增加(P<0.05).结论DHA复合物能显著降低H-Ras癌基因的转录,并能显著增加p16押癌基因的转录,从而抑制肿瘤细胞的增殖。 |
| English Summary: |
| Objective To study the antitumor mechanism of DHA compound. Methods RT-PCR was used to investigate the effects of DHA compound on H-Ras and pl6 mRNA transcription in gastric adenocarcinoma. Results Compared with control, the content of H-Ras mRNA was decreased and the content of p16 mRNA was increased in gastric adenocarcinoma significantly after treated with DHA compound. Conclusion The transcription of H-Ras gene was decreased and the transcription of pl6 gene was increased in gastric adenocarcinoma after treated with DHA compound and thus the cancer cell growth was inhibited. |
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