| .异丁基壳聚糖多功能敷料的生物安全性[J].中国海洋药物,2005,24(5):39-42. |
| 异丁基壳聚糖多功能敷料的生物安全性 |
| Study on the bio-safety of a multifunctional dressing based onisobutyl-chitosan |
| 投稿时间：2004-11-12 |
| DOI： |
| 中文关键词: 创面敷料 异丁基壳聚糖 致敏作用 刺激作用 全身急性毒性 |
| English Keywords:wound dressing isobutyl-chitosan sensitization irritation systemic acute toxicity |
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| 中文摘要: |
| 目的 研究以壳聚糖衍生物-异丁基壳聚糖为生物基质材料而制成的多功能（止血、镇痛、抗菌、促愈合）创面敷料的安全性。方法 采用皮肤刺激、皮内刺激、眼刺激法考察其刺激作用；利用皮肤斑贴试验观察其致敏作用；采用腹腔注射法观察其全身急性毒性作用。结果 异丁基壳聚糖多功能敷料无刺激、无致敏及无明显急性毒性。结论 异丁基壳聚糖多功能敷料具有良好的生物安全性。 |
| English Summary: |
| Objective To study the bio-safety of a multifunctional dressing based on isobutyl-chitosan, a derivative of chitosan. Methods To investigate the local irritation of the multifunctional dressing by skin, subcutaneous and eye application, determine its sensitization by patch test and observe its systemic acute toxicity by abdominal injection. Results The isobutyl-chitosan multifunctional dressing had no irritation, sensitization and systemic acute toxicity. Conclusion The isobutyl-chitosan multifunctional dressing has a good bio-safety as a wound dressing. |
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