| .二十二碳六烯酸乙酯对脑缺血再灌注氧化损伤及脑水肿的影响[J].中国海洋药物,2004,23(5):21-25. |
| 二十二碳六烯酸乙酯对脑缺血再灌注氧化损伤及脑水肿的影响 |
| Protective effects of ethyl docosahexaenoate on brain oxidative injury and edema induced by cerebral ischemic reperfusion |
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| 中文关键词: 二十二碳六烯酸乙酯 脑缺血再灌注损伤 自由基 脑水肿 |
| English Keywords:ethyl docosahexaenoate(E-DHA),cerebral ischemic reperfusive injury,free radicals,brain edema |
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| 中文摘要: |
| 目的 研究二十二碳六烯酸乙酯(ethyl docosahexaenoate，E-DHA)对沙土鼠脑缺血再灌注引起的氧化损伤和脑水肿的保护作用。方法 采用沙土鼠双侧颈总动脉阻断法制作全脑缺血再灌注损伤模型。检测E-DHA对缺血再灌注后脑中丙二醛(MDA)和谷胱甘肽(GSH)含量；谷胱甘肽过氧化物酶(GSH-Px)、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、ATP酶活性；水及Na^ 、Ca^2 含量的影响．并进行了病理检查。结果 缺血前E-DHA预防给药10周有效阻止了脑缺血再灌注引起的MDA升高，GsH降低，GsH-Px、CAT活性降低．ATP酶活性降低，水及Ca^2 、Na^ 含量升高。结论 E-DHA对沙土鼠脑缺血再灌注具有保护作用，其机理与清除自由基和减轻脑水肿有关。 |
| English Summary: |
| Objective To investigate the protective effects of ethyl docosahexaenoate on brain oxidative injury and edema induced by cerebral ischemic/reperfusion in gerbils. Methods The gerbils were subjected to both common carotid arteries occlusion. The contents of MDA and GSH, the activities of GSH-PX, CAT, SOD and ATPase, the water content and the concentrations of Na + and Ca 2+ were measured. Histopathological examination was also done. Results The pretreatment with E-DHA significantly prevented the raise of MDA level, the decline of GSH content, the activities of GSH-Px, CAT, ATPase and the increases of Ca 2+, Na + and water content. Conclusion E-DHA has protective effect on brain ischemic injury and edema, which may be due to an inhibitory action on hydroxyl radical formation and brain edema. |
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