| .藻酸双酯钠对早期糖尿病肾病血浆内皮素和血小板功能的影响[J].中国海洋药物,2004,23(3):36-38. |
| 藻酸双酯钠对早期糖尿病肾病血浆内皮素和血小板功能的影响 |
| Effects of PSS on ET-1 secretion and platelet functions in the patients with early diabetic nephropathy |
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| DOI： |
| 中文关键词: 藻酸双酯钠 糖尿病肾病 内皮素（ET—1） 血脂 血液流变学 |
| English Keywords:polysaccharide sulfate (PSS),diabetic nephropathy(DN),Endothelin-1 (ET-1),blood lipid,hemorrheology |
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| 中文摘要: |
| 目的 探讨藻酸双酯钠(PSS)注射液防治早期糖尿病肾病的疗效及作用机理。方法 选择早期糖尿病肾病患者76例，给予PSS注射液100mg，加入0．9％氯化钠注射液250mL静滴，每日1次，连续14d。观察用药前后血浆内皮素(ET-1)，血小板活性指标TXB2、6-Keto—PGF1a及全血黏度、血浆黏度、血清TG、TC、HDL-C、LDL—C以及24h尿蛋白定量的变化。结果 用药后上述指标均有显著性改善。结论 PSS注射液可通过调节ET-1及TXB2／6-Keto—PGF1a降低血脂、血黏度，改善肾脏微循环，减少尿蛋白的排出，防治糖尿病的早期肾损害。 |
| English Summary: |
| Objective To investigate the effects and mechanism of action of PSS on the treatment of patients with early DN. Methods 76 patients with early DN were given PSS 100mg(iv gtt, qd) for 14 days. ET-1, TXB_2, 6-Keto-PGF_(1a), blood viscosity TG, TC, HDL-C, LDL-C and urine protein quantity(24h UPQ) were determined and compared between before and after treatment. Results All indexes above were improved significantly after therapy. Conclusion PSS may modulate ET-1 secretion and the ratio of TXB_2/6-Keto-PGF_(1a), reduce blood lipid content and viscosity, improve hemorrheology in patients with early DN. |
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