| .鲨肝活性肽S-8300对小鼠急性肝损伤的保护作用[J].中国海洋药物,2004,23(1):17-20. |
| 鲨肝活性肽S-8300对小鼠急性肝损伤的保护作用 |
| Protective effect of peptide S-8300 from shark liver on acute liver Injury in mice |
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| DOI： |
| 中文关键词: 鲨肝活性肽S-8300 四氯化碳 实验性肝损伤 |
| English Keywords:Peptide S 8300 from shark liver,CCl 4,experimental hepatic injury |
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| 中文摘要: |
| 目的：研究鲨肝活性肽S-8300对四氯化碳(CCl4)小鼠肝损伤的保护作用。方法：采用CCl4致小鼠肝损伤，观察肝组织切片；测定生化指标，检测小鼠腹腔注射S-8300后血清谷丙转氨酶(sGPT)、血清谷草转氨酶(sGOT)和乳酸脱氢酶(LDH)活性，肝脏超氧化物歧化酶(SOD)活性与丙二醛(MDA)和谷胱甘肽(GSH)含量。结果：S-8300能明显减轻CCl4所致小鼠急性肝损伤；降低血清GPT、GOT、LDH活性及降低肝组织MDA含量，增加肝组织GSH含量和提高SOD活性。结论：鲨肝活性肽S-8300对急性肝损伤有明显的保护作用。 |
| English Summary: |
| Objective To study the hepatoprotective effect of peptide S 8300 from shark liver on CCl 4 induced liver injury in mice. Methods Mice were administered ip with three doses of S 8300 for four consecutive days, followed by CCl 4 ip on d3. The activity of SGPT, SGOT, LDH, and liver SOD as well as contents of MDA and GSH in the mice liver were tested. Results S 8300 can decrease obviously the levels of SGPT, SGOT, LDH activities and liver MDA content in liver injury mice caused by CCl 4 , increase SOD activities and the content of GSH of the liver. Conclusion S 8300 has significant protective effects on experimental liver injury mice. |
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