| .水溶性异丁基壳聚糖的生物安全性评价[J].中国海洋药物,2003,22(4):30-33. |
| 水溶性异丁基壳聚糖的生物安全性评价 |
| Evaluation of bio-compatibility on water soluble isobutyl-chitosan |
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| DOI： |
| 中文关键词: 异丁基壳聚糖 细胞毒性 致敏作用 刺激作用 全身急性毒性作用 |
| English Keywords:isobutyl-chitosan,cytotoxicity,sensitization,irritation,systemic acute toxicity |
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| 中文摘要: |
| 目的：评价异丁基壳聚糖作为生物材料的安全性。方法：采用细胞生长抑制法测定其细胞毒性；利用接触斑贴试验测定其致敏作用；根据皮肤刺激试验、眼刺激试验、皮内刺激试验考察其刺激作用；采用腹腔注射试验观察其全身急性毒性作用。结果：异丁基壳聚糖无细胞毒性、无致敏、刺激及全身毒性作用。结论：水溶性的异丁基壳聚糖可作为一种安全无毒的生物材料。 |
| English Summary: |
| Objective To evaluate the bio-compatibility of isobutyl-chitosan as a material. Methods To determine the cytotoxicity of isobutyl-chitosan by the inhibition of cell growth; To investigate it's sensitization through patch test; To investigate it's irritation on skin, eyes and intradermis by tests of patch and intradermic injection; To investigate it's systemic acute tox-icity by peritoneal injection. Results The isobutyl-chitosan has no cytotoxicity, sensitization, irritation and systemic acute toxicity. Conclusion The water-soluble isobutyl-chitosan has a good biocompatibility as a material. |
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