| .褐藻淀粉硫酸酯对实验性动脉粥样硬化预防作用的机理研究[J].中国海洋药物,2002,21(5):26-30. |
| 褐藻淀粉硫酸酯对实验性动脉粥样硬化预防作用的机理研究 |
| Study on the mechanism of laminarin sulfate in the prevention of experimental atherosclerosis |
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| 中文关键词: 褐藻淀粉硫酸酯 动脉粥样硬化 白细胞介素 肿瘤坏死因子 免疫功能 药理 |
| English Keywords:Laminarin sulfate,Atherosclerosis,Interleukins,Tumor nercosis factor,Immu-nologic function |
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| 中文摘要: |
| 目的：探讨海洋药物褐藻淀粉硫酸酯对实验性动物粥样硬化预防作用的免疫学机理，方法：用酶联免疫吸附，放射免疫等方法测定了实验动物大鼠及鹌鹑的血清可溶性白介素2受体，免疫复合物，T淋巴细胞亚群，细胞因子及血脂代谢等指标。结果：高脂动物血脂代谢及免疫功能和细胞因子发生了明显紊乱，药物则有明显的调节作用，同时对脂肪酸代谢等亦有很强的调节作用。结论：褐藻淀粉硫酸酯对实验性动物粥样硬化的预防作用是对多种因素作用的结果。 |
| English Summary: |
| Objective To explore the possible immunological mechanism of laminarin sulfate in the prevention of experimental atherosclerosis. Methods Serum soluble interleukin 2 receptor (sIL-2R) , circulating immuno-complex, sub units of T lymphocyte, inter leukin-6(IL-6) , in-terleukin-8(IL-8), tumor necrosis factor-a (TNF-a) and lipid metabolism were determined by ELISA, RIA in rats and quails. Results The lipid metabolism and immunologic function were prominent disturbance in animals after feeding with high-lipid food. However, Laminarin sulfate has obvious regulating effects on above-mentioned index. Conclusions The mechanism of laminarin sulfate in the prevention of atherosclerosis might be closely related to the regulation of the disturbance of lipid metabolism and to the regulation of the immunologic function of the body. |
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