| .几丁糖酯抗动脉粥样硬化作用研究[J].中国海洋药物,2001,20(1):12-16,27. |
| 几丁糖酯抗动脉粥样硬化作用研究 |
| Studies on the antiatherosclerotic effects of chitosan ester |
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| DOI： |
| 中文关键词: 几丁糖酯 壳聚糖 高脂血症 血管平滑肌细胞 动脉粥样硬化 动物模型 |
| English Keywords:chitosan ester,chitosan,hyperlipidemia,vascular smooth muscle cells,atherosclerosis |
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| 中文摘要: |
| 用高脂膳食喂养家兔建立动脉粥样硬化模型，观察几丁糖酯对脂质代谢及主动脉斑块形成的影响，结果表明，几丁糖酯可以降低家兔血清中甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）及丙二醛（MDA）含量，升高高密度脂蛋白胆固醇（HDL-C），减轻肝脏脂肪样变，砬轻主动脉斑块形成程度；在体外培养牛主动脉平滑肌细胞，观察几丁糖酯对细胞增殖的影响。结果表明，几丁糖酯可抑制血管平滑肌细胞增殖。透射电镜观察，给药组细胞呈现收缩型的形态学特征，而对照组则呈现合成型的特征。 |
| English Summary: |
| The in vivo antiatherosclerotic effect of chitosan ester was evaluated in diet induced hyperlipidemia rabbits. The results showed that comparison with hyperlipidemia model, chitosan ester decreased TC, TG, LDL C and MDA, but increased HDL C markedly. The formation of fatty liver and atherosclerotic plaque was decreased in chitosan ester groups. In another study the antiproliferative effect of chitosan ester on cultured bovine aortic smooth muscle cells (BASMCs) were observed. Chitosan ester was found to inhibit the proliferation of BASMCs in vitro, and it could also keep the cells in a contractile phenotype. |
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