| .鳗鱼油精对胶原诱导的兔和大鼠血小板聚集和血栓素B2产生的影响[J].中国海洋药物,1998,17(4):46-48. |
| 鳗鱼油精对胶原诱导的兔和大鼠血小板聚集和血栓素B2产生的影响 |
| EFFECTS OF THE PURIFIED OIL OF ANGUILLA JAPONICA ON PLATELET AGGREGATION AND THROBOXANE B_2 PRODUCTION INDUCED BY COLLAGEN IN RABBITS AND RATS |
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| 中文关键词: 鳗鱼油精 胶原 血小板聚集 血栓素B2 |
| English Keywords:purified oil of Anguilla japonica(POAJ),collagen,platelet aggregation,throm-boxane B2,turbidimetry,radioimmunoassay |
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| 中文摘要: |
| 用比浊法和放射免疫法测定了鳗鱼油精对血小板聚集和血栓素Ｂ２产生的影响。结果表明，①体外试验：１０．４￣８３．３ｍｌ／Ｌ鳗鱼油精明显抑制胶原诱导的兔血小板聚集和血栓素Ｂ２（ＴＸＢ２）产生，前者的抑制率为２０．５％￣６４．２％，后者的抑制率为１８．２％￣６１．０％。鳗鱼油精的浓度与抑制血小板聚集和ＴＸＢ２产生的效力呈正相关性，同时血小板聚集的抑制率和ＴＸＢ２产生的抑制率之间也呈正相关性，三者的线性方程 |
| English Summary: |
| Turbidimetry and radioimmunoassay were used to determine the effect of the Purified Oil of Anguilla japonica(POAJ)on platelet aggregation and thromboxane B2 production. In vitro experiment the results showed that POAJ (10. 4-83. 3ml/L)inhibited colla-geninduced platelet aggregation and TXB2 production significantly. Their inhibition rates were 20. 5%-64. 2%andl8. 2%-61. 0% ,respectively. There was correlation between POAJ concentration and efficiency of inhibition of platelet aggregation and TXB2 production, and also between inhibition rates of platelet aggregation and that of TXB2 production. The linear e-quations and main parameters were Y=-0. 7672 + 0. 0724X,r=0. 9880(P<0. 01), Y = -0.0268+0. 0023X,r=0. 9959(P<0. 05)Y = -0. 5623 + 0. 9763X,r=0. 9968(P<0. 05). In vivo experiment ,at day 15 or 30 after oral administration of POAJ,the inhibition rates were 28. 0%or 44. 5%for platelet aggregation,and the reduction rates were 24. 6%or 53. 4%for TXB2 production,respectively. |
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