| .甘糖酯对家兔全脑缺血再灌损伤的保护作用[J].中国海洋药物,1998,17(4):15-17. |
| 甘糖酯对家兔全脑缺血再灌损伤的保护作用 |
| PROTECTIVE EFFECTS OF PROPYLENE GLYCOL MANNATE SULFATE ON THE WHOLE CEREBRAL LSCHEMIA/REPERFU-SION INJURY IN RABBITS |
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| 中文关键词: 甘糖酯 脑缺血 再灌注损伤 药物疗法 脑保护作用 |
| English Keywords:propylene glycol mannate sulfate,whole cerebral ischemia/reperfusioninjury,malondehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),brain water content,nitric oxide (NO) |
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| 中文摘要: |
| 甘糖酯是一种新型的低分子量、低抗凝活性的多糖类海洋药物。本文报道甘糖酯对４动脉阻断家兔全脑缺血再灌损伤脑组织过氧化脂质（ＭＤＡ）、超氧化物歧化酶（ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）、一氧化氮（ＮＯ）和脑含水量的影响。结果显示，甘糖酯可降低全脑缺血再灌损伤的ＭＤＡ含量，提高ＳＯＤ和ＧＳＨ－Ｐｘ活性，降低脑含水量，对ＮＯ无明显影响，提示甘糖酯对全脑再灌损伤有明显的抗氧化作用。 |
| English Summary: |
| The effects of propylene glycol mannate sulfate (PGMS) on the lipid peroxide (MDA) , superoxide dismutase (SOD) , glutathion peroxidase (GSH-Px), nitric oxide (NO)and water content in the whole cerebral ischemia/reperfusion injury rabbits induced by four-vessel occlusion,The results show that PGMS can decrease the brain water and MDA, and can increase the SOD and GSH-Px level. No significant effect on the NO level has been detected. The results suggest that the protective effects of PGMS on ischemia/reperfusion injury may be related to its antioxidation. |
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