| .海洋毒素柳珊瑚酸的羧基改造及其毒理研究[J].中国海洋药物,1996,15(1):1-4. |
| 海洋毒素柳珊瑚酸的羧基改造及其毒理研究 |
| CARBOXYLIC DERIVATIVES OF SUBERGORGIC ACID AND THEIR TOXICOLOGY |
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| DOI： |
| 中文关键词: 海洋神经毒素 柳珊瑚酸 构效关系 毒理学 羧基 |
| English Keywords:Coral neurotoxin,subergorgic acid,derivatives,toxicology |
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| 中文摘要: |
| 从柳珊瑚酸合成出６个新神经活性物质，药理实验和构效关系研究表明，柳瑚酸分子作用于乙酰胆碱酸酶，并可地抑制其水解活性。 |
| English Summary: |
| Six new sesquiterpenoid compounds of nerve-activity were synthesized from a gorgonian neurotoxin -subergorgic acid (1). Toxicological studies and structural correlation with toxicity reveal that subergorgic acid may act on cholinesterase and make a reversible inhibition of its activity of hydrolysis. |
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