| .甘糖酯在小鼠体内的药代动力学研究[J].中国海洋药物,1995,14(2):15-17. |
| 甘糖酯在小鼠体内的药代动力学研究 |
| STUDIES ON THE IN VIVO PHARMACOKINETICS OF PROPYLENE GLYCOL MANNURATE SULFATE IN MICE |
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| DOI： |
| 中文关键词: 甘糖酯 药代动力学 吸收 分布 |
| English Keywords:propylene glycol mannurate sulfate (PGMS),pharmacokinetics,absorption,distribution,excreAon |
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| 中文摘要: |
| 用同位素标记法研究了[~3H]甘糖酯1次灌胃后在小鼠体内的药代动力学,其血药浓度——时间曲线符合一室开放模型。小鼠灌服[~3H]甘糖酯25mg/kg(4.48MB_q/kg)后的药动学参数为:t_(1/2)Ka 0.24h;t_(1/2)β67h,V_d921mL,Cl9.58ml/h,AUC41.45mg/(mL·h),F79.3％,PPB54.9％。该药广泛分布于肝、肾、脾、胸腺、肾上腺、肺、心、肌肉和脑内。主要经尿道与粪便排泄。 |
| English Summary: |
| The in vivo pharmacokinetics of Propylene Glycol Mannuratae Sulfate (PGMS) after acute administration in mice was studied by the radio isotope assay. Its concentration -time curve fitted the one -compartment model. The pharmacokinetic indice of oral administration of PGMS 25 mg/kg are as follow;t1/2 Ka 0. 24 h,t1/2 B 67 h,Vd 927 mL,C1 9. 58 mL/h,AUC 41. 45 ng/(ml - h), F 79. 3%,PPB (plasma protein binding) 54. 9%. The drug was widely distributed in the liver,kidney,spleen,thymus,adrenal gland,lung,heart, muscles and brain,and excreted mainly through urine and feces. |
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